Association of contrast sensitivity with LogMAR visual acuity and glycosylated hemoglobin in non-insulin dependent diabetes mellitus

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• 作者：Shaili Misra (1)
  Sandeep Saxena (1)
  Poonam Kishore (1)
  Shashi K. Bhasker (1)
  Arvind Misra (2)
  Carsten H. Meyer (3)
  
• 关键词：Contrast sensitivity ; Non ; insulin dependent diabetes mellitus ; LogMAR visual acuity ; Glycosylated hemoglobin
• 刊名：Journal of Ocular Biology, Diseases, and Informatics
• 出版年：2010
• 出版时间：June 2010
• 年：2010
• 卷：3
• 期：2
• 页码：60-63
• 全文大小：183KB
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• 作者单位：Shaili Misra (1)
  Sandeep Saxena (1)
  Poonam Kishore (1)
  Shashi K. Bhasker (1)
  Arvind Misra (2)
  Carsten H. Meyer (3)
  
  1. Department of Ophthalmology, C.S.M. Medical University (erstwhile King George’s Medical University), Lucknow, India
  2. Department of Internal Medicine, C.S.M. Medical University (erstwhile King George’s Medical University), Lucknow, India
  3. Department of Ophthalmology, University of Bonn, Bonn, Germany
  

文摘

A tertiary care center-based prospective case–control study was undertaken to evaluate the association of contrast sensitivity with LogMAR visual acuity and glycosylated hemoglobin (HbA1c) in 205 cases of non-insulin dependent diabetes mellitus and 115 controls. LogMAR visual acuity and contrast sensitivity were scored using ETDRS and Pelli-Robson charts, respectively. Bivariate correlation between contrast sensitivity and LogMAR visual acuity showed significant inverse correlation in cases without retinopathy (r-??0.466) and with non-proliferative retinopathy (r-??0.307). In a multivariate model, on applying linear regression analysis, LogMAR visual acuity (p-lt;-.001) and HbA1c (p--.002) had significant association with contrast sensitivity. Significant difference in contrast sensitivity was not observed between cases without diabetic retinopathy and with non-proliferative diabetic retinopathy, implying no association with retinal microvascular changes. Contrast sensitivity dysfunction observed in diabetes mellitus results from changes in retinal function secondary to alteration in carbohydrate metabolism depicted in glycosylated hemoglobin.