Motor function is associated with 1,25(OH)2D and indices of insulin–glucose dynamics in non-diabetic older adults

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• 作者：Jamie N. Justice (1)
  Lauren A. Pierpoint (1)
  Diba Mani (1)
  Robert S. Schwartz (2)
  Roger M. Enoka (1)
  
• 关键词：Aging ; Physical function ; Vitamin D ; Insulin resistance ; Endurance
• 刊名：Aging Clinical and Experimental Research
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：26
• 期：3
• 页码：249-254
• 全文大小：
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• 作者单位：Jamie N. Justice (1)
  Lauren A. Pierpoint (1)
  Diba Mani (1)
  Robert S. Schwartz (2)
  Roger M. Enoka (1)
  
  1. University of Colorado Boulder, 354 UCB, Boulder, CO, 80309-0354, USA
  2. University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA
  
• ISSN：1720-8319

文摘

Background Advancing age is accompanied by changes in metabolic characteristics, such as reduced insulin sensitivity and low levels of vitamin D, which may exacerbate age-related declines in physical function. Aims The aim of the present study was to determine the associations between insulin–glucose dynamics, vitamin D metabolites, and performance on a battery of motor tasks in healthy, non-diabetic older adults. Methods Sixty-nine community-dwelling men and women (65-0?years) were recruited. Insulin–glucose dynamics were determined by an intravenous glucose tolerance test, and vitamin D metabolites were measured. Motor function was characterized by the time to walk 500?m, chair-rise time, lower body strength, dorsiflexor steadiness and endurance time, and muscle coactivation. Results Significant unadjusted correlations were found between insulin–glucose dynamics and 1,25-dihydroxyvitamin D [1,25(OH)2D] with walk time, strength, steadiness, endurance time, and muscle activation (p?<?0.05). A significant amount of the variance in walking endurance was explained by the sex of the individual, 1,25(OH)2D, and fasting blood insulin (R 2?=?0.36, p?<?0.001). Strength could be partially explained by age, body fatness, and fasting glucose (R 2?=?0.55, p?<?0.001). Discussion Poor motor function in non-diabetic older men and women was associated with indices of insulin–glucose dynamics and the bio-active vitamin D metabolite 1,25(OH)2D. Walking endurance and strength were explained by 1,25(OH)2D and fasting blood glucose and insulin, even after adjusting for age, sex, and body fat. Conclusion Motor function in a relatively small sample of non-diabetic older men and women was associated with metabolic factors that increase in prevalence with aging.