The Use of Exosomes as Biomarkers for Evaluating and Monitoring Critically Ill Polytrauma Patients with Sepsis

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• 作者：Marian Ticlea ; Lavinia Melania Bratu ; Florian Bodog…
• 关键词：Sepsis ; Exosomal miRNAs ; Epigenetic biomarkers ; Critically ill polytrauma patient
• 刊名：Biochemical Genetics
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：55
• 期：1
• 页码：1-9
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Human Genetics; Biochemistry, general; Zoology; Medical Microbiology;
• 出版者：Springer US
• ISSN：1573-4927
• 卷排序：55

文摘

Regarding genetic biomarkers for early assessment and monitoring the clinical course in polytrauma patients with sepsis, in recent years a remarkable evolution has been highlighted. One of the main representatives is the exosome miRNAs. In this paper, we would like to present in more details the various methods of using exosome miRNAs as a biomarker for monitoring polytrauma patients with sepsis, as well as establishing a belated outcome by aggregating the entire clinical aspects. The use of exosome miRNAs for late evaluating and monitoring the clinical evolution of polytrauma patients can bring significant improvements in current clinical practice through the optimization and modulation of intensive care according to the needs of each patient individually.