Hemostasis Plug for an Electromagnetic Thermotherapy and Its Application for Liver Laceration

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• 作者：Chung-Hsien Liu ; Sheng-Chieh Huang ; Ying-Jui Chao…
• 关键词：Hemostasis ; Electromagnetic thermotherapy ; Laceration
• 刊名：Annals of Biomedical Engineering
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：44
• 期：4
• 页码：1310-1320
• 全文大小：3,276 KB
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• 作者单位：Chung-Hsien Liu (1)
  Sheng-Chieh Huang (1)
  Ying-Jui Chao (4)
  Xi-Zhang Lin (5)
  Gwo-Bin Lee (1) (2) (3)
  
  1. Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan
  4. Department of Surgery, National Cheng Kung University, Tainan, 701, Taiwan
  5. Department of Internal Medicine, National Cheng Kung University, Tainan, 701, Taiwan
  2. Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan
  3. Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu, 300, Taiwan
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Biomedicine
  Biomedical Engineering
  Biophysics and Biomedical Physics
  Mechanics
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-9686

文摘

Accident-induced liver trauma is a significant human health concern, as this organ is readily injured during periods at which the abdominal region is compromised. In this work, electromagnetic thermotherapy was successfully developed and employed in vitro and in vivo to treat livers that had been lacerated. Briefly, a new hemostasis plug was integrated with an electromagnetic thermotherapy system (ETS) to perform surgery on lacerated livers. The high-frequency, alternating electromagnetic field (EMF) was generated by the ETS and was shown to induce a pre-set temperature increase within the hemostasis plug embedded in the target tissue. In order to prevent overheating and maintain a constant hemostasis temperature, a temperature feedback control system was utilized. The effect of the intensity of the EMF on the heating capacity of the ETS-hemostasis system was first explored. Furthermore, the relationship between the coagulation zone and operating temperature were investigated in vitro. By utilizing the temperature feedback control system, the hemostasis plug could be heated to a specific temperature for efficient hemostasis. With this approach, the optimal treatment temperature and time were investigated for liver laceration. Lacerated livers from New Zealand white rabbits were successfully treated with the hemostasis plug and ETS within a short period of time. When compared with the traditional perihepatic packing approach, the volume of blood loss from liver laceration surgeries treated by ETS has been dramatically reduced by 83%, suggesting a high therapeutic potential for this system.