Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer

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• 作者：Shegan Gao ; Shuoguo Li ; Zhikun Ma ; Shuo Liang ; Tanyou Shan…
• 关键词：Porphyromonas gingivalis ; ESCC ; Lys ; gingipain ; 16S rDNA ; Oral pathogen ; Differentiation ; Metastasis ; Overall survival rate ; Prognoses
• 刊名：Infectious Agents and Cancer
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：11
• 期：1
• 全文大小：1,692 KB
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• 作者单位：Shegan Gao (1)
  Shuoguo Li (1)
  Zhikun Ma (1)
  Shuo Liang (1)
  Tanyou Shan (1)
  Mengxi Zhang (1)
  Xiaojuan Zhu (1)
  Pengfei Zhang (1)
  Gang Liu (1)
  Fuyou Zhou (2)
  Xiang Yuan (1)
  Ruinuo Jia (1)
  Jan Potempa (3) (4)
  David A. Scott (4)
  Richard J. Lamont (4)
  Huizhi Wang (4)
  Xiaoshan Feng (1) (5)
  
  1. Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, China
  2. Department of Oncology, Anyang People’s Hospital, Anyang, 471500, China
  3. Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland
  4. Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Room 263D, 501 South Preston Street, Louisville, KY, 40202, USA
  5. Department of Oncology, Henan University of Science and Technology, 24 Jinghua Road, Jianxi Qu, Luoyang, 471500, Henan, China
  
• 刊物主题：Cancer Research; Infectious Diseases; Oncology;
• 出版者：BioMed Central
• ISSN：1750-9378

文摘

Background Mounting evidence suggests a causal relationship between specific bacterial infections and the development of certain malignancies. However, the possible role of the keystone periodontal pathogen, Porphyromonas gingivalis, in esophageal squamous cell carcinoma (ESCC) remains unknown. Therefore, we examined the presence of P. gingivalis in esophageal mucosa, and the relationship between P. gingivalis infection and the diagnosis and prognosis of ESCC.