Characterization of anticonvulsant and antiepileptogenic potential of thymol in various experimental models

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• 作者：Jayant Sancheti (1)
  Mohd Farooq Shaikh (1) (2)
  Rahul Chaudhari (1)
  Gauresh Somani (1)
  Sachin Patil (1)
  Pankaj Jain (1)
  Sadhana Sathaye (1)
  
• 关键词：Maximal electroshock ; Pentylenetetrazole ; Strychnine ; 4 ; Aminopyridine ; GABAA receptors ; Sodium Channels
• 刊名：Naunyn-Schmiedeberg's Archives of Pharmacology
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：387
• 期：1
• 页码：59-66
• 全文大小：
• 作者单位：Jayant Sancheti (1)
  Mohd Farooq Shaikh (1) (2)
  Rahul Chaudhari (1)
  Gauresh Somani (1)
  Sachin Patil (1)
  Pankaj Jain (1)
  Sadhana Sathaye (1)
  
  1. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai, 400019, Maharashtra, India
  2. Brain Research Institute, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Sunway Campus, Petaling Jaya, Selangor, 46150, Malaysia
  
• ISSN：1432-1912

文摘

The present study was to investigate the anticonvulsant and antiepileptogenic potential of thymol. Anticonvulsant activity of thymol (500mg/kgi.p.) was studied using maximal electroshock, pentylenetetrazole (PTZ), strychnine and 4-aminopyridine (4-AP) models. Thymol at the selected dose was also studied for its effect on locomotion. Antiepileptogenic property of thymol (55mg/kg) was evaluated using PTZ-induced kindling model along with its effect on malondialdehyde and glutathione levels. Thymol (50 and 100mg/kg, i.p.) showed anticonvulsant activity against maximal electroshock and pentylenetetrazole (66.66 and 83.33% protection at 50 and 100mg/kg, respectively) model but not against strychnine and 4-aminopyridine models. Thymol exhibited decreased locomotor activity in dose-dependent manner at the same dose range. Thymol at the dose of (25mg/kg, i.p.) significantly decreased the seizure score, increased glutathione levels and decreased malondialdehyde levels in pentylenetetrazole-induced kindling model. Thymol exhibited significant anticonvulsant and antiepileptogenic property.