Serum Urea:Albumin Ratio as a Prognostic Marker in Critical Patients With Non-Chronic Kidney Disease

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• 作者：D. B. Gundpatil (1)
  B. L. Somani (1)
  T. K. Saha (1)
  M. Banerjee (1)
  
• 关键词：Urea ; albumin ratio (UAR) ; Critical patients ; Non ; CKD ; Stay ; Mortality ; Threshold level
• 刊名：Indian Journal of Clinical Biochemistry
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：29
• 期：1
• 页码：97-100
• 全文大小：250 KB
• 作者单位：D. B. Gundpatil (1)
  B. L. Somani (1)
  T. K. Saha (1)
  M. Banerjee (1)
  
  1. Department of Biochemistry, Armed Forces Medical College, Pune, 411040, Maharashtra, India
  
• ISSN：0974-0422

文摘

Routine laboratory investigations play an important role in estimating the risk of mortality in intensive care unit (ICU) patients. The significance of urea:albumin ratio (UAR) in predicting the stay and mortality of ICU patients is not known. It is a retrospective study of patients admitted to ICU (n?=?412) with non-chronic kidney disease (non-CKD). Receiver-operating characteristics (ROC) analysis for predicting mortality was carried out to find area under curve (AUC) and threshold levels. Analysis of survival probability was carried out by Kaplan–Meier method and Log-rank test. The AUC to predict mortality were 0.695, 0.767 and 0.791 for serum albumin, urea and UAR, respectively. The threshold levels for albumin, urea and UAR were 2.8?g/dL, 53?mg/dL, and 23.44?mg/g, respectively. The highest odds ratio (OR) of 9.75 to predict mortality at threshold level was observed for UAR, while OR were 7.0 and 3.62 for serum urea and albumin, respectively. The serum urea above and albumin below threshold level were associated with increase in ICU stay of >3?days but the highest OR of 4.73 to predict stay of >3?days was observed for UAR. Kaplan–Meier survival analysis shows significant (p?<?0.001) difference at the threshold value of UAR. Serum urea and albumin are found to be an independent predictor for the mortality and stay; however an increased UAR value is the best parameter in predicting mortality and stay in ICU patients with non-CKD illness.