Prognostic value of blood flow estimated by arterial spin labeling and dynamic susceptibility contrast-enhanced MR imaging in high-grade gliomas

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• 作者：Mandy Kim Rau (1)
  Christian Braun (2)
  Marco Skardelly (3)
  Jens Schittenhelm (4)
  Frank Paulsen (5)
  Benjamin Bender (1)
  Ulrike Ernemann (1)
  Sotirios Bisdas (1)
  
• 关键词：Gliomas ; Blood flow ; Arterial spin labeling ; Blood volume
• 刊名：Journal of Neuro-Oncology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：120
• 期：3
• 页码：557-566
• 全文大小：747 KB
• 参考文献：1. Law M, Young R, Babb J, Rad M, Sasaki T, Zagzag D, Johnson G (2006) Comparing perfusion metrics obtained from a single compartment versus pharmacokinetic modeling methods using dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade. AJNR Am J Neuroradiol 27(9):1975-982
  2. Law M, Yang S, Babb JS, Knopp EA, Golfinos JG, Zagzag D, Johnson G (2004) Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade. AJNR Am J Neuroradiol 25(5):746-55
  3. Law M, Oh S, Babb JS, Wang E, Inglese M, Zagzag D, Knopp EA, Johnson G (2006) Low-grade gliomas: dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging–prediction of patient clinical response. Radiology 238(2):658-67. doi:10.1148/radiol.2382042180 CrossRef
  4. Bisdas S, Kirkpatrick M, Giglio P, Welsh C, Spampinato MV, Rumboldt Z (2009) Cerebral blood volume measurements by perfusion-weighted MR imaging in gliomas: ready for prime time in predicting short-term outcome and recurrent disease? AJNR Am J Neuroradiol 30(4):681-88. doi:10.3174/ajnr.A1465 CrossRef
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  11. Lehmann P, Monet P, de Marco G, Saliou G, Perrin M, Stoquart-Elsankari S, Bruniau A, Vallee JN (2010) A comparative study of perfusion measurement in brain tumours at 3 Tesla MR: arterial spin labeling versus dynamic susceptibility contrast-enhanced MRI. Eur Neurol 64(1):21-6. doi:10.1159/000311520 CrossRef
  12. White CM, Pope WB, Zaw T, Qiao J, Naeini KM, Lai A, Nghiemphu PL, Wang JJ, Cloughesy TF, Ellingson BM (2014) Regional and Voxel-Wise Comparisons of Blood Flow Measurements Between Dynamic Susceptibility Contrast Magnetic Resonance Imaging (DSC-MRI) and Arterial Spin Labeling (ASL) in Brain Tumors. J Neuroimaging 24(1):23-0. doi:Sotirios Bisdas (1)
  
  1. Department of Neuroradiology, Eberhard Karls University, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany
  2. Department of Neurology, Eberhard Karls University, Tübingen, Germany
  3. Department of Neurosurgery, Eberhard Karls University, Tübingen, Germany
  4. Department of Neuropathology, Eberhard Karls University, Tübingen, Germany
  5. Department of Radiation Oncology, Eberhard Karls University, Tübingen, Germany
  
• ISSN：1573-7373

文摘

Several studies evaluated the predictive value of dynamic susceptibility contrast enhanced (DSC) imaging and arterial spin labeling (ASL) with regard to histological grade. Yet still less is known about their significance in terms of patients prognosis. Our purpose was to evaluate the agreement between them and the prognostic value of ASL- and DSC-CBF measurements for time-to-recurrence (TTR). Sixty nine cases of WHO Grade 3- gliomas underwent both DSC- and ASL-MRI. Normalized ASL and DSC-based cerebral blood flow (CBF) maps as well as DSC-derived cerebral blood volume maps (CBV) were analyzed. Wilcoxon test and Bland–Altman plot analysis were applied in order to compare DSC-rCBF and ASL-rCBF. Spearman’s rank correlation coefficients were determined for all perfusion parameters. Receiver operating characteristic (ROC) curve and survival curve analyses were performed. The median values of ASL-rCBF, DSC-rCBF, and DSC-rCBV were 5.3, 6.9, and 8.0, respectively. There was neither significant correlation nor difference between ASL-rCBF and DSC-rCBF. Slight proportional bias was demonstrated in the Bland–Altman plot analysis of ASL-rCBF and DSC-rCBF values. Unlikely to DSC-rCBV, DSC- and ASL-based rCBF parameters demonstrated moderate sensitivity and specifitity for tumor recurrence but no statistical significance regarding their prognostic values for TTR in the Kaplan–Meier analysis. There were neither correlation nor interchangeability between the DSC-rCBF and ASL-rCBF estimations, which demonstrated comparable, though not significant prognostic value for the prediction of TTR. rCBV measurements seem to provide the best sensitivity and specificity to predict tumor recurrence and survival time in these patients.