B-Type Natriuretic Peptide-Guided Risk Assessment for Postoperative Complications in Lung Cancer Surgery
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  • 作者:Takashi Nojiri ; Masayoshi Inoue ; Yasushi Shintani…
  • 刊名:World Journal of Surgery
  • 出版年:2015
  • 出版时间:May 2015
  • 年:2015
  • 卷:39
  • 期:5
  • 页码:1092-1098
  • 全文大小:225 KB
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  • 刊物类别:Medicine
  • 刊物主题:Medicine & Public Health
    Surgery
    Abdominal Surgery
    Cardiac Surgery
    General Surgery
    Thoracic Surgery
    Vascular Surgery
  • 出版者:Springer New York
  • ISSN:1432-2323
文摘
Background Since lung cancer surgery is still associated with a high complication rate, it is important to efficiently identify patients at high risk for postoperative complications following lung cancer surgery. We previously reported that elderly patients with elevated preoperative B-type natriuretic peptide (BNP) levels (>30?pg/mL) have an increased risk for postoperative atrial fibrillation and cardiopulmonary complications following lung cancer surgery. The objective of this study was to evaluate the clinical utility of BNP-guided risk classification for postoperative complications after lung cancer surgery. Methods A total of 675 consecutive patients who underwent curative surgery for lung cancer in two specialized thoracic centers between 2007 and 2011 were included in this retrospective study. We evaluated the association between the incidence of postoperative complications and preoperative BNP levels. Results Univariable and multivariable stepwise logistic regression analyses revealed that an elevated preoperative BNP level was the most significant predictor of postoperative complications. All patients were classified by their preoperative BNP levels into a normal group (100?pg/mL). The incidence of postoperative complications was significantly higher in the severely and mildly elevated groups than in the control group (85?% and 47?% vs. 11?%, P? Conclusions Risk assessment using preoperative BNP levels was clinically useful for the identification of patients at high risk for postoperative complications.
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