Impact of synthetic ghrelin administration for patients with severe body weight reduction more than 1 year after gastrectomy: a phase II clinical trial

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• 作者：Shuji Takiguchi ; Yasuhiro Miyazaki ; Tsuyoshi Takahashi ; Yukinori Kurokawa…
• 关键词：Ghrelin ; Gastric cancer ; Body weight loss
• 刊名：Surgery Today
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：46
• 期：3
• 页码：379-385
• 全文大小：479 KB
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• 作者单位：Shuji Takiguchi (1)
  Yasuhiro Miyazaki (1)
  Tsuyoshi Takahashi (1)
  Yukinori Kurokawa (1)
  Makoto Yamasaki (1)
  Kiyokazu Nakajima (1)
  Hiroshi Miyata (1)
  Hiroshi Hosoda (2)
  Kenji Kangawa (2)
  Masaki Mori (1)
  Yuichiro Doki (1)
  
  1. Division of Gastroenterological Surgery, Department of Surgery, Graduate School of Medicine, Osaka University, 2-2, E2, Yamadaoka, Suita, Osaka, 565-0871, Japan
  2. Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Surgery
  Abdominal Surgery
  Thoracic Surgery
  Vascular Surgery
  Cardiac Surgery
  Surgical Oncology
  
• 出版者：Springer Japan
• ISSN：1436-2813

文摘

Purpose Ghrelin is mainly secreted from the stomach and plays a role in appetite, weight gain, and the promotion of a positive energy balance. The levels of ghrelin decrease immediately after gastrectomy. We herein investigated the effect of the administration of synthetic ghrelin to treat postoperative severe weight loss in a prospective, one-arm clinical trial to develop new strategies for weight gain.