Predictive factors of the pharmacological action of tolvaptan in patients with liver cirrhosis: a post hoc analysis

详细信息    查看全文

• 作者：Isao Sakaida ; Shuji Terai ; Koji Nakajima…
• 关键词：Tolvaptan ; Liver cirrhosis ; Initial urine volume ; Ascites ; related clinical symptom ; Predictive factor
• 刊名：Journal of Gastroenterology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：52
• 期：2
• 页码：229-236
• 全文大小：457KB
• 刊物类别：Medicine
• 刊物主题：Gastroenterology; Hepatology; Abdominal Surgery; Colorectal Surgery; Surgical Oncology;
• 出版者：Springer Japan
• ISSN：1435-5922
• 卷排序：52

文摘

BackgroundTolvaptan has been approved in Japan for the treatment of hepatic edema. An important consideration in providing a clinical benefit to patients with liver cirrhosis is the improvement of ascites-related clinical symptoms. In the present post hoc analysis, we aimed to identify factors that were predictive of the potency of tolvaptan, and to examine the relationship between changes in initial urine volume and improvement in ascites-related clinical symptoms.