Synthesis and antimicrobial activity of some new triazino-, triazolo-, and pyrazolopyridazine derivatives

详细信息    查看全文

• 作者：F. A. Yassin
• 关键词：diethyl malonate ; ethyl acetoacetate ; ethylbenzoylacetate ; ethyl cyanoacetate ; hydrazinopyridazine ; phenacyl bromide ; pyrazolopyridazine ; triazinopyridazine ; thiazolopyridazine
• 刊名：Chemistry of Heterocyclic Compounds
• 出版年：2009
• 出版时间：August, 2009
• 年：2009
• 卷：45
• 期：8
• 页码：997-1003
• 全文大小：337.6 KB

文摘

The reaction of 3-hydrazino-4,5,6-triphenylpyridazine with phenacyl bromide afforded triazolopyridazine, while the reaction with different aldehydes gave the corresponding 3-arylidene hydrazinopyridazine derivatives which, on reaction with Br₂/Na₂CO₃, gave the corresponding triazinopyridazines. Also, fusion with ethyl acetoacetate, ethyl benzoylacetate, diethyl malonate, or ethyl phenylacetoacetate gave the corresponding pyrazolo- and triazinopyridazine derivatives. The antimicrobial activity of some of the new compounds has been discussed.