Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility

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• 作者：Mamoona Noreen ; Muhammad Arshad
• 关键词：Polymorphism ; Disease ; Susceptibility ; Toll like receptors ; Mal/TIRAP
• 刊名：Immunologic Research
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：62
• 期：2
• 页码：234-252
• 全文大小：967 KB
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• 作者单位：Mamoona Noreen (1)
  Muhammad Arshad (2)
  
  1. Atta-ur-Rehman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), H-12 Sector, Islamabad, Pakistan
  2. Department of Zoology, University of Sargodha, Sargodha, Pakistan
  
• 刊物主题：Allergology; Immunology; Medicine/Public Health, general; Internal Medicine;
• 出版者：Springer US
• ISSN：1559-0755

文摘

Toll like receptors (TLRs) play a crucial role in regulation of innate as well as adaptive immunity. TLRs recognize a distinct but limited repertoire of conserved microbial products. Ligand binding to TLRs activates the signaling cascade and results in activation of multiple inflammatory genes. Variation in this immune response is under genetic control. Polymorphisms in genes associated with inflammatory pathway especially influence the outcome of diseases. TLR2 makes heterodimer with TLR1 or TLR6 and recognizes a wide variety of microbial ligands. In this review, we summarize studies of polymorphisms in genes encoding TLR1, TLR2, TLR4, TLR6, and most polymorphic adaptor protein, Mal/TIRAP, revealing their effect on susceptibility to diseases.