Diagnostic imaging of dementia with Lewy bodies by susceptibility-weighted imaging of nigrosomes versus striatal dopamine transporter single-photon emission computed tomography: a retrospective observational study

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• 作者：Koji Kamagata ; Tomoya Nakatsuka ; Ryuji Sakakibara ; Yohei Tsuyusaki…
• 关键词：Alzheimer’s disease ; Dementia ; Dopamine ; Lewy bodies ; Parkinson disease
• 刊名：Neuroradiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：1
• 页码：89-98
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Neuroradiology; Imaging / Radiology; Neurology; Neurosurgery; Neurosciences;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1920
• 卷排序：59

文摘

IntroductionThe characteristics of dementia with Lewy bodies (DLB), Alzheimer’s disease (AD) and amnestic mild cognitive impairment (a-MCI) overlap but require different treatments; therefore, it is important to differentiate these pathologies. Assessment of dopamine uptake in the striatum using dopamine transporter (DaT) single-photon emission computed tomography (SPECT) is the gold standard for diagnosing DLB; however, this modality is expensive, time consuming and involves radiation exposure. Degeneration of the substantia nigra nigrosome-1, which occurs in DLB, but not in AD/a-MCI, can be identified by 3T susceptibility-weighted imaging (SWI). Therefore, the aim of this retrospective observational study was to compare SWI with DaT-SPECT for differentiation of DLB from AD/a-MCI.