Chronopharmacokinetics of once daily dosed aminoglycosides in hospitalized infectious patients

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• 作者：Erik van Maarseveen (1) (5)
  Wai Hong Man (1)
  Johannes Proost (2)
  Cees Neef (3)
  Dani毛l Touw (4)
  
  1. Department of Clinical Pharmacy ; University Medical Center Utrecht ; Heidelberglaan 100 ; 3584 CX ; Utrecht ; The Netherlands
  5. Department of Clinical Pharmacy ; University Medical Center Utrecht ; Room HP D00.218 ; Heidelberglaan 100 ; P.O. Box 85500 ; 3508 GA ; Utrecht ; The Netherlands
  2. Department of Pharmacokinetics ; Faculty of Mathematic and Natural Sciences ; University of Groningen ; Broerstraat 5 ; 9700 AB ; Groningen ; The Netherlands
  3. Department of Clinical Pharmacy and CAHPRI ; Maastricht University Medical Center ; P. Debyelaan 25 ; 6229 HX ; Maastricht ; The Netherlands
  4. Department of Clinical Pharmacy and Pharmacology ; University Medical Center Groningen ; P.O. Box 30.001 (internal post code EB70) ; 9700 RB ; Groningen ; The Netherlands
  
• 关键词：Aminoglycosides ; Circadian ; Diurnal ; Gentamicin ; Nephrotoxicity ; Pharmacokinetics ; Tobramycin
• 刊名：Pharmacy World Science
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：37
• 期：2
• 页码：342-347
• 全文大小：182 KB
• 参考文献：1. Beaucaire G, Leroy O, Beuscart C, Karp P, Chidiac C, Caillaux M. Clinical and bacteriological efficacy, and practical aspects of amikacin given once daily for severe infections. J Antimicrob Chemother. 1991;27(Suppl C):91鈥?03.
  2. Munckhof, WJ, Grayson, ML, Turnidge, JD (1996) A meta-analysis of studies on the safety and efficacy of aminoglycosides given either once daily or as divided doses. J Antimicrob Chemother 37: pp. 645-663 CrossRef
  3. Buijk, SE, Mouton, JW, Gyssens, IC, Verbrugh, HA, Bruining, HA (2002) Experience with a once-daily dosing program of aminoglycosides in critically ill patients. Intensive Care Med 28: pp. 936-942 CrossRef
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  5. Hatala, R, Dinh, T, Cook, DJ (1996) Once-daily aminoglycoside dosing in immunocompetent adults: a meta-analysis. Ann Intern Med 124: pp. 717-725 CrossRef
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  7. Hosokawa, H, Nyu, S, Nakamura, K, Mifune, K, Nakano, S (1993) Circadian variation in amikacin clearance and its effects on efficacy and toxicity in mice with and without immunosuppression. Chronobiol Int 10: pp. 259-279 CrossRef
  8. Song, J, Ohdo, S, Ogawa, N, Nakano, S (1993) Influence of feeding schedule on chronopharmacological aspects of gentamicin in mice. Chronobiol Int 10: pp. 338-348 CrossRef
  9. Yoshiyama, Y, Kobayashi, T, Tomonaga, F (1992) Chronotoxical study of gentamicin induced nephrotoxicity in rats. J Antibiot (Tokyo) 45: pp. 806-808 CrossRef
  10. Yoshiyama, Y, Nishikawa, S, Sugiyama, T, Kobayashi, T, Shimada, H, Tomonaga, F (1993) Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats. Antimicrob Agents Chemother 37: pp. 2042-2043 CrossRef
  11. Dickson, CJ, Schwartzman, MS, Bertino, JS (1986) Factors affecting aminoglycoside disposition: effects of circadian rhythm and dietary protein intake on gentamicin pharmacokinetics. Clin Pharmacol Ther 39: pp. 325-328 CrossRef
  12. Yoshiyama, Y, Grenier, L, Gourde, P, Simard, M, Lin, L, Morin, NJ (1996) Temporal variation in nephrotoxicity of low doses of isepamicin in rats. Antimicrob Agents Chemother 40: pp. 802-806
  13. Beauchamp, D, Labrecque, G (2007) Chronobiology and chronotoxicology of antibiotics and aminoglycosides. Adv Drug Deliv Rev 59: pp. 896-903 CrossRef
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  16. Fauconneau, B, Lemos, E, Pariat, C, Bouquet, S, Courtois, P, Piriou, A (1992) Chronotoxicity in rat of a vancomycin and gentamicin combination. Pharmacol Toxicol 71: pp. 31-36 CrossRef
  17. Lin, L, Grenier, L, Bergeron, Y, Simard, M, Bergeron, MG, Labrecque, G (1994) Temporal changes of pharmacokinetics, nephrotoxicity, and subcellular distribution of tobramycin in rats. Antimicrob Agents Chemother 38: pp. 54-60 CrossRef
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Pharmacy
  
• 出版者：Springer Netherlands
• ISSN：2210-7711

文摘

Background hospitalized patients with serious infections treated with aminoglycosides are at risk of developing nephrotoxicity. Previous clinical studies have shown that the pharmacokinetics of aminoglycosides in humans follow a circadian rhythm. Therefore, the time of administration could have important clinical implications with respect to the risk of developing aminoglycoside-associated nephrotoxicity in patients treated with once daily dosing regimens. Objective To examine the effect of the time period of administration on aminoglycoside exposure and the incidence of nephrotoxicity in a large population of hospitalized patients with serious infections. Setting General ward and intensive care unit of a teaching hospital. Method In this retrospective cohort study, patients treated with intravenous tobramycin or gentamicin were eligible for inclusion. Patients were divided into three groups by time of administration: morning, afternoon and night. Main outcome measure Pharmacokinetic parameters and the incidences of nephrotoxicity were compared between the morning, afternoon and evening groups. Results 310 general ward and 411 intensive care unit patients were included. No significant differences were found in patient characteristics between the morning, afternoon and night groups. The time period of administration did not affect aminoglycoside pharmacokinetics or the incidence of nephrotoxicity. Conclusion The time of administration has no effect on the pharmacokinetics or nephrotoxicity of once daily dosed aminoglycosides in hospitalized patients. Consequently, we advise aminoglycosides to be administered as soon as possible in case of (suspected) severe hospital-acquired infections and subsequent dosages to be based on therapeutic drug monitoring to optimize the efficacy/toxicity balance.