Hypoxia-inducible factor 1 and breast cancer metastasis
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  • 作者：Zhao-ji Liu (1)
    Gregg L. Semenza (2)
    Hua-feng Zhang (1)

    1. CAS Key Laboratory of Innate Immunity and Chronic Disease     ; Innovation Center for Cell Biology ; School of Life Sciences ; University of Science and Technology of China ; Hefei ; 230027 ; China
    2. Johns Hopkins University School of Medicine     ; Baltimore ; MD ; 21205 ; USA
  • 关键词：Breast cancer ; Hypoxia ; inducible factor 1 (HIF ; 1) ; Metastasis ; R737.9 ; Q2 ; 涔宠吅鐧?/li> 浣庢哀璇卞鍥犲瓙 ; 鑲跨槫杞Щ
  • 刊名：Journal of Zhejiang University SCIENCE B
  • 出版年：2015
  • 出版时间：January 2015
  • 年：2015
  • 卷：16
  • 期：1
  • 页码：32-43
  • 全文大小：743 KB
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  • 刊物主题：Biomedicine general;
  • 出版者：Springer Berlin Heidelberg
  • ISSN：1862-1783
文摘
Accumulating evidence has shown that the hypoxic microenvironment, which is critical during cancer development, plays a key role in regulating breast cancer progression and metastasis. The effects of hypoxia-inducible factor 1 (HIF-1), a master regulator of the hypoxic response, have been extensively studied during these processes. In this review, we focus on the roles of HIF-1 in regulating breast cancer cell metastasis, specifically its effects on multiple key steps of metastasis, such as epithelial-mesenchymal transition (EMT), invasion, extravasation, and metastatic niche formation. We also discuss the roles of HIF-1-regulated non-coding RNAs in breast cancer metastasis, and therapeutic opportunities for breast cancer through targeting the HIF-1 pathway.
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