Does the Solid-Phase Synthesis of a Tetrapeptide Represent a Challenge at the Onset of the XXI Century? The Case of Cyclo [(3 R )-3-hydroxydecanoyl-l -seryl-(3 R )-3-hydroxydecanoy

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• 作者：Meritxell Teixidó ; Josep Maria Caba ; Roger Prades ; Esther Zurita ; Marc Martinell ; Marta Vilaseca ; Fernando Albericio and Ernest Giralt
• 关键词：serratamolide ; tetradepsipeptide ; solid ; phase synthesis ; cyclization
• 刊名：International Journal of Peptide Research and Therapeutics
• 出版年：2007
• 出版时间：June, 2007
• 年：2007
• 卷：13
• 期：1-2
• 页码：313-327
• 全文大小：585 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Animal Anatomy, Morphology and Histology
  Polymer Sciences
  
• 出版者：Springer Netherlands
• ISSN：1573-3904

文摘

At the beginning of the XXI century, 43 years after the description of the first solid-phase synthesis of a tetrapeptide by Bruce Merrifield, the synthesis of a tetrapeptide may still represent a synthetic challenge. This is the case of serratamolide, a cyclic tetradepsipeptide originally found in a culture of Serratia marcescens, which exhibits interesting properties as a chemotherapeutic agent. Here we explore several methodologies for the synthesis of serratamolide in order to find a strategy that allows its preparation for further biological studies.