Effects of corticosteroid plus long-acting beta₂-agonist on the expression of PD-L1 in double-stranded RNA-induced lung inflammation in mice

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• 作者：Saaka Hamano ; Koichiro Matsumoto ; Ken Tonai ; Satoru Fukuyama…
• 关键词：Asthma ; Viral infection ; Lung inflammation ; Corticosteroid ; Long ; acting beta2 ; agonist
• 刊名：Journal of Inflammation
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：14
• 期：1
• 全文大小：2969KB
• 刊物主题：Immunology; Allergology; Cytokines and Growth Factors; Rheumatology; Pharmacology/Toxicology; Gastroenterology;
• 出版者：BioMed Central
• ISSN：1476-9255
• 卷排序：14

文摘

BackgroundAirway viral infections cause the exacerbations of asthma and chronic obstructive pulmonary disease. PD-L1, also known as B7-H1, is an immune-checkpoint molecule that plays a role in an escape mechanism of viruses from the host immune systems. This escape may be associated with the persistence of viral infection and the exacerbation of the underlying diseases. In a study in vitro, we have shown that corticosteroids plus long-acting beta₂-agonists (LABAs) attenuate the upregulation of PD-L1 on airway epithelial cells stimulated with an analog of viral double-stranded RNA, polyinosinic-polycytidylic acid (poly I:C). To address its biological relevance in vivo, we investigated the effect of corticosteroid plus LABA on the expression of PD-L1 in double-stranded RNA-induced lung inflammation in mice.