Fluorescent dyes as a reliable tool in P2X7 receptor-associated pore studies

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• 作者：Leonardo Ferreira ; Luíza Pereira ; Robson Faria
• 关键词：Fluorescence ; Fluorescent dyes ; Ion channels
• 刊名：Journal of Bioenergetics and Biomembranes
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：47
• 期：4
• 页码：283-307
• 全文大小：2,000 KB
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• 作者单位：Leonardo Ferreira (1)
  Luíza Pereira (1)
  Robson Faria (1)
  
  1. Laboratory of Cellular Communication, Oswaldo Cruz Foundation, Av. Brazil 4365, pavilion 108, room 28B Manguinhos, Rio de Janeiro, Brazil, CEP 21040-360
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Bioorganic Chemistry
  Biochemistry
  Animal Anatomy, Morphology and Histology
  Animal Biochemistry
  Organic Chemistry
  
• 出版者：Springer New York
• ISSN：1573-6881

文摘

Since the nineteenth century, a great amount of different biological structures and processes have been assessed by fluorescent dyes. Along with the uses of these compounds as vital and histological dyes, some fluorescent dyes have become valuable tools for the study of the pore phenomenon in plasma membranes. Some ion channels capable of forming large conductance channels, such as P2X7, TRPV1, VDAC-1 and the maxi-anion channels transiently alter the plasma membrane permeability, producing pores, which permit the passage of molecules of up to 1,000 Da. In this review, we discuss the uses of the fluorescent dyes chosen in diverse studies of this topic up to now. Keywords Fluorescence Fluorescent dyes Ion channels