Targeted imaging and induction of apoptosis of drug-resistant hepatoma cells by miR-122-loaded graphene-InP nanocompounds

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• 作者：Xin Zeng ; Yi Yuan ; Ting Wang ; Han Wang ; Xianyun Hu ; Ziyi Fu…
• 关键词：Graphene oxide ; Quantum dots ; MiR ; 122 ; Cell apoptosis ; Near infrared ; Liver cancer
• 刊名：Journal of Nanobiotechnology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：15
• 期：1
• 全文大小：1661KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Biotechnology; Nanotechnology; Molecular Medicine;
• 出版者：BioMed Central
• ISSN：1477-3155
• 卷排序：15

文摘

BackgroundCurrently, graphene oxide has attracted growing attention as a drug delivery system due to its unique characteristics. Furthermore, utilization of microRNAs as biomarkers and therapeutic strategies would be particularly attractive because of their biological mechanisms and relatively low toxicity. Therefore, we have developed functionalized nanocompounds consisted of graphene oxide, quantum dots and microRNA, which induced cancer cells apoptosis along with targeted imaging.