| |
Prognostic significance of XIAP and NF-κB expression in esophageal carcinoma with postoperative radiotherapy
- 作者：Suna Zhou (1)
Wenguang Ye (2)
Qiuju Shao (1)
Yuhong Qi (1)
Mingxin Zhang (2)
Jun Liang (1)
- 关键词：Esophageal squamous cell carcinoma ; X ; chromosome ; linked IAP ; Nuclear factor ; κB
- 刊名：World Journal of Surgical Oncology
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：11
- 期：1
- 全文大小：301 KB
- 参考文献：1. Hiyama T, Yoshihara M, Tanaka S, Chayama K: Genetic polymorphisms and esophageal cancer risk. / Int J Cancer 2007,121(8):1643-658. CrossRef
2. Yuequan J, Shifeng C, Bing Z: Prognostic factors and family history for survival of esophageal squamous cell carcinoma patients after surgery. / Ann Thorac Surg 2010,90(3):908-13. CrossRef
3. Nakagawa S, Kanda T, Kosugi S, Ohashi M, Suzuki T, Hatakeyama K: Recurrence pattern of squamous cell carcinoma of the thoracic esophagus after extended radical esophagectomy with three-field lymphadenectomy. / J Am Coll Surg 2004,198(2):205-11. CrossRef
4. Miyazaki T, Kato H, Faried A, Sohda M, Nakajima M, Fukai Y, Masuda N, Manda R, Fukuchi M, Ojima H, Tsukada K, Kuwano H: Predictors of response to chemo-radiotherapy and radiotherapy for esophageal squamous cell carcinoma. / Anticancer Res 2005,25(4):2749-755.
5. Li BZ, Chen ZL, Shi SS, Feng XL, Tan XG, Zhou F, He J: Overexpression of Cdc25C predicts response to radiotherapy and survival in esophageal squamous cell carcinoma patients treated with radiotherapy followed by surgery. / Chin J Cancer 2013. doi:10.5732/cjc.012.10233. [Epub ahead of print]
6. Fulda S, Vucic D: Targeting IAP proteins for therapeutic intervention in cancer. / Nat Rev Drug Discov 2012,11(2):109-24. CrossRef
7. Eckelman BP, Salvesen GS, Scott FL: Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. / EMBO Rep 2006,7(10):988-94. CrossRef
8. Vucic D: Targeting IAP, (inhibitor of apoptosis) proteins for therapeutic intervention in tumors. / Curr Cancer Drug Targets 2008,8(2):110-17. CrossRef
9. Sasaki H, Sheng Y, Kotsuji F, Tsang BK: Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells. / Cancer Res 2000,60(20):5659-666.
10. Hu Y, Cherton-Horvat G, Dragowska V, Baird S, Korneluk RG, Durkin JP, Mayer LD, LaCasse EC: Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo . / Clin Cancer Res 2003,9(7):2826-836.
11. Bilim V, Kasahara T, Hara N, Takahashi K, Tomita Y: Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug-resistant TCC in vitro . / Int J Cancer 2003,103(1):29-7. CrossRef
12. McManus DC, Lefebvre CA, Cherton-Horvat G, St-Jean M, Kandimalla ER, Agrawal S, Morris SJ, Durkin JP, Lacasse EC: Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics. / Oncogene 2004,23(49):8105-117. CrossRef
13. Zhang S, Ding F, Luo A, Chen A, Yu Z, Ren S, Liu Z, Zhang L: XIAP is highly expressed in esophageal cancer and its downregulation by RNAi sensitizes esophageal carcinoma cell lines to chemotherapeutics. / Cancer Biol Ther 2007,6(6):973-80.
14. Ohnishi K, Scuric Z, Schiestl RH, Okamoto N, Takahashi A, Ohnishi T: siRNA targeting NBS1 or XIAP increases radiation sensitivity of human cancer cells independent of TP53 status. / Radiat Res 2006,166(3):454-62. CrossRef
15. Kim DW, Seo SW, Cho SK, Chang SS, Lee HW, Lee SE, Block JA, Hei TK, Lee FY: Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells. / J Orthop Res 2007,25(6):820-28. CrossRef
16. Giagkousiklidis S, Vellanki SH, Debatin KM, Fulda S: Sensitization of pancreatic carcinoma cells for gamma-irradiation-induced apoptosis by XIAP inhibition. / Oncogene 2007,26(49):7006-016. CrossRef
17. Wang R, Li B, Wang X, Lin F, Gao P, Cheng SY, Zhang HZ: Inhibiting XIAP expression by RNAi to inhibit proliferation and enhance radiosensitivity in laryngeal cancer cell line. / Auris Nasus Larynx 2009,36(3):332-39. CrossRef
18. Connolly K, Mitter R, Muir M, Jodrell D, Guichard S: Stable XIAP knockdown clones of HCT116 colon cancer cells are more sensitive to TRAIL, taxanes and irradiation in vitro . / Cancer Chemother Pharmacol 2009,64(2):307-16. CrossRef
19. Moussata D, Amara S, Siddeek B, Decaussin M, Hehlgans S, Paul-Bellon R, Mornex F, Gerard JP, Romestaing P, R?del F, Flourie B, Benahmed M, Mauduit C: XIAP as a radioresistance factor and prognostic marker for radiotherapy in human rectal adenocarcinoma. / Am J Pathol 2012,181(4):1271-278. CrossRef
20. Ahn KS, Aggarwal BB: Transcription factor NF-kappaB: a sensor for smoke and stress signals. / Ann N Y Acad Sci 2005, 1056:218-33. CrossRef
21. Dolcet X, Llobet D, Pallares J, Matias-Guiu X: NF-kB in development and progression of human cancer. / Virchows Arch 2005,446(5):475-82. CrossRef
22. Lu M, Lin SC, Huang Y, Kang YJ, Rich R, Lo YC, Myszka D, Han J, Wu H: XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. / Mol Cell 2007,26(5):689-02. CrossRef
23. Hatata T, Higaki K, Tatebe S, Shomori K, Ikeguchi M: Immunohistochemical study of nuclear factor-κB expression in esophageal squamous cell carcinoma: prognostic significance and sensitivity to treatment with 5-FU. / Dis Esophagus 2012,25(8):716-22. CrossRef
24. Xiao ZF, Yang ZY, Liang J, Miao YJ, Wang M, Yin WB, Gu XZ, Zhang DC, Zhang RG, Wang LJ: Value of radiotherapy after radical surgery for esophageal carcinoma: a report of 495 patients. / Ann Thorac Surg 2003,75(2):331-36. CrossRef
25. Chen J, Zhu J, Pan J, Zhu K, Zheng X, Chen M, Wang J, Liao Z: Postoperative radiotherapy improved survival of poor prognostic squamous cell carcinoma esophagus. / Ann Thorac Surg 2010,90(2):435-42. CrossRef
26. Chen J, Pan J, Zheng X, Zhu K, Li J, Chen M, Wang J, Liao Z: Number and location of positive nodes, postoperative radiotherapy, and survival after esophagectomy with three-field lymph node dissection for thoracic esophageal squamous cell carcinoma. / Int J Radiat Oncol Biol Phys 2012,82(1):475-82. CrossRef
27. Vogler M, Walczak H, Stadel D, Haas TL, Genze F, Jovanovic M, Bhanot U, Hasel C, M?ller P, Gschwend JE, Simmet T, Debatin KM, Fulda S: Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma. / Cancer Res 2009,69(6):2425-434. CrossRef
28. Cao C, Mu Y, Hallahan DE, Lu B: XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer. / Oncogene 2004,23(42):7047-052. CrossRef
29. Vellanki SH, Grabrucker A, Liebau S, Proepper C, Eramo A, Braun V, Boeckers T, Debatin KM, Fulda S: Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma. / Neoplasia 2009,11(8):743-52.
30. Ohnishi K, Nagata Y, Takahashi A, Taniguchi S, Ohnishi T: Effective enhancement of X-ray-induced apoptosis in human cancer cells with mutated p53 by siRNA targeting XIAP. / Oncol Rep 2008,20(1):57-1.
31. Gyrd-Hansen M, Meier P: IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. / Nat Rev Cancer 2010,10(8):561-74. CrossRef
32. Ramp U, Krieg T, Caliskan E, Mahotka C, Ebert T, Willers R, Gabbert HE, Gerharz CD: XIAP expression is an independent prognostic marker in clear-cell renal carcinomas. / Hum Pathol 2004,35(8):1022-028. CrossRef
33. Li M, Song T, Yin ZF, Na YQ: XIAP as a prognostic marker of early recurrence of nonmuscular invasive bladder cancer. / Chin Med J (Engl) 2007,120(6):469-73.
- 作者单位：Suna Zhou (1)
Wenguang Ye (2)
Qiuju Shao (1)
Yuhong Qi (1)
Mingxin Zhang (2)
Jun Liang (1)
1. Department of Radiotherapy, Tangdu Hospital, Fourth Military Medical University, Xinsi Road 1, Xi’an, Shaanxi, China
2. Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xinsi Road 1, Xi’an, Shaanxi, China
- ISSN：1477-7819
文摘
Background X-chromosome-linked IAP (XIAP) and nuclear factor-κB (NF-κB) are frequently overexpressed and correlate closely with chemoradiotherapy resistance and poor prognosis in many cancers. However, the significance of XIAP and NF-κB expression in radiotherapy sensitivity and its effect on the prognosis of esophageal squamous cell carcinoma (ESCC) are still unknown. The aim of this study was to examine XIAP and NF-κB status in ESCC patients undergoing postoperative radiotherapy after radical surgery, and to evaluate their clinical significance. Methods A total of 78 ESCC patients treated with postoperative radiotherapy after radical surgery were enrolled in this study. We immunohistochemically investigated the expression of XIAP and NF-κB in tissues from enrolled patients with specific antibodies. Then, the correlations among XIAP, NF-κB expression, clinicopathological features and its prognostic relevance in ESCC were analyzed. Results The increased expression of XIAP and NF-κB in ESCC tissues were clearly correlated with the tumor differentiation and p-TNM stage. Significant positive correlations were found between the expression status of XIAP and NF-κB (r--.779, P--.000). Overexpression of XIAP and NF-κB and metastasis were significantly associated with shorter overall survival times in univariate analysis (P-lt;-.05). Multivariate analysis also confirmed that XIAP expression was an independent prognostic factor (P--.005). Conclusions XIAP and NF-κB are intensively expressed in ESCC. The level of XIAP is positively correlated to progression and prognosis of ESCC.
| |
NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.
| |
