Thermo-chemotherapy Induced miR-218 upregulation inhibits the invasion of gastric cancer via targeting Gli2 and E-cadherin

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• 作者：Qiang Ruan ; Zhi-yuan Fang ; Shu-zhong Cui ; Xiang-liang Zhang ; Yin-bing Wu…
• 关键词：Thermo ; chemotherapy ; miR ; 218 ; Gli2 ; Tumor invasion ; Gastric cancer ; E ; cadherin
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：36
• 期：8
• 页码：5807-5814
• 全文大小：2,190 KB
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• 作者单位：Qiang Ruan (1)
  Zhi-yuan Fang (1)
  Shu-zhong Cui (1)
  Xiang-liang Zhang (1)
  Yin-bing Wu (1)
  Hong-sheng Tang (1)
  Yi-nuo Tu (1)
  Yan Ding (1)
  
  1. Department of Hepatobiliary Surgery, Cancer Institute and Hospital, Guangzhou Medical University, Guangzhou, 510095, Guangdong, China
  
• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

Thermo-chemotherapy has been proven to reduce the invasion capability of cancer cells. However, the molecular mechanism underlying this anti-invasion effect is still unclear. In this study, the role of thermo-chemotherapy in the inhibition of tumor invasion was studied. The results demonstrated that expression of miR-218 was downregulated in gastric cancer tissues, which had a positive correlation with tumor invasion and metastasis. In vitro thermo-chemotherapy increased miR-218 expression in SGC7901 cells and inhibited both proliferation and invasion of cancer cells. Gli2 was identified as a downstream target of miR-218, and its expression was negatively regulated by miR-218. The thermo-chemotherapy induced miR-218 upregulation was also accompanied by increasing of E-cadherin expression. In conclusion, the present study indicates that thermo-chemotherapy can effectively decrease the invasion capability of cancer cells and increase cell-cell adhesion. miR-218 and its downstream target Gli2, as well as E-cadherin, participate in the anti-invasion process. Keywords Thermo-chemotherapy miR-218 Gli2 Tumor invasion Gastric cancer E-cadherin