Interaction between TNFR1 and TNFR2 dominates the clinicopathologic features of human hypopharyneal carcinoma

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• 作者：Xiuru Ma ; Xiaoming Li ; Xiuying Lu ; Lifeng Jia ; Hui Li ; Qi Song
• 关键词：Tumor necrosis factor receptor (TNFR) ; Hypopharyngeal squamous cell carcinoma ; Clinicopathologic factor ; Receptor interaction ; Cell proliferation
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：36
• 期：12
• 页码：9421-9429
• 全文大小：1,735 KB
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• 作者单位：Xiuru Ma (1) (2)
  Xiaoming Li (1) (2)
  Xiuying Lu (2)
  Lifeng Jia (2)
  Hui Li (2)
  Qi Song (2)
  
  1. Postgraduate School, Hebei Medical University, Shijiazhuang, Hebei, China
  2. Department of Otolaryngology Head and Neck Surgery, Bethune International Peace Hospital, Zhongshan West Street 398, Shijiazhuang, 050081, People’s Republic of China
  
• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

Although the expression of tumor necrosis factor receptors (TNFRs) has been associated with clinicopathologic features of some other cancers, their roles in hypopharyngeal squamous cell carcinoma (HPSCC) have not been documented. Forty-five HPSCC specimens were analyzed for the expression of TNFR1 and TNFR2 and its relationship with clinicopathologic factors. Interaction between the two receptors and its effects on TNF-α was investigated by neutralizing TNFR1 and upregulation of TNFR2. The results indicated that, in HPSCC specimens, the expression of TNFR1 but not TNFR2 is associated with clinical staging, T stage, cervical lymph node metastasis, and histologic grade in HPSCC. In Fadu cells, when conjugating with its receptors, TNF-α mediates proliferation effects, and neutralizing TNFR1 and/or upregulating TNFR2 evokes proliferation-inhibiting and apoptosis-inducing effects and potentiates cisplatin (DDP)-induced growth inhibition and apoptosis induction. In conclusion, interaction of TNFR1 with TNFR2 determines the biological characters of HPSCC, and TNFR1 may dominate this process. Moreover, interaction between the two receptors plays important roles in determining the fates of HPSCC cells and thus may serve as a therapeutic target for developing new therapeutic strategies for HPSCC. Keywords Tumor necrosis factor receptor (TNFR) Hypopharyngeal squamous cell carcinoma Clinicopathologic factor Receptor interaction Cell proliferation