文摘

Porcine reproductive and respiratory syndrome (PRRS) is a swine disease of major economic importance that causes reproductive and respiratory problems in pigs. In the present study, one strain of porcine reproductive and respiratory syndrome virus (PRRSV) was isolated in Xinjiang province, Northwest China, designated XJu-1. The full-length genome of XJu-1 was found to be 14,987 nucleotides in length, including the poly(A) tail. Comparative analysis with the genomic sequences of type 2 isolates revealed that XJu-1 shared 87.2-9.2?% identity with these isolates, but only 60.4?% with the type 1 virus—Lelystad Virus, indicating that this new Chinese isolate was closely related to the North American PRRSV genotype. XJu-1 was a novel strain with unique deletions in NSP2 region, namely that 150-amino acid deletion in NSP2. The genomic variations of XJu-1 strain provided the basis for further studies of virulence determinants and evolution for PRRSVs.