Genistein protects against Aβ_25–35 induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers

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• 作者：Fuling You ; Qiao Li ; Guifang Jin ; Yaojie Zheng ; Jingrong Chen…
• 关键词：Alzheimer’s disease ; Aβ25–35 ; Apoptosis ; Genistein ; JNK ; Bcl ; 2
• 刊名：BMC Neuroscience
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：1384KB
• 刊物主题：Neurosciences; Neurobiology; Animal Models;
• 出版者：BioMed Central
• ISSN：1471-2202
• 卷排序：18

文摘

BackgroundDeposition of aggregated amyloid beta (Aβ) protein is hallmark of Alzheimer’s disease, leading to dysfunction and apoptosis of neurons. The isoflavone phytoestrogen compound genistein (Gen) exerts a significant protective effect against Aβ_25–35 induced neurotoxicity and mitochondrial damage in rat pheochromocytoma (PC12) cells. However, the mechanisms underlying Gen’s rescue remain elusive. Therefore we endeavored to research further the molecular mechanisms underlying Gen’s inhibition of Aβ_25–35 induced apoptosis of neurons.