Survey of enterovirus infections from hand, foot and mouth disease outbreak in china, 2009

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• 作者：Fan Yang (1)
  Ting Zhang (1)
  Yongfeng Hu (1)
  Xiaofang Wang (2)
  Jiang Du (1)
  Yufen Li (3)
  Shaoxia Sun (3)
  Xiuhua Sun (4)
  Zhifang Li (3)
  Qi Jin (1)
  
• 关键词：Hand ; Foot and Mouth Disease ; enterovirus ; human enterovirus 71 ; coxsackie virus A16 ; coxsackie virus B5
• 刊名：Virology Journal
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：8
• 期：1
• 全文大小：245KB
• 参考文献：1. Blomqvist S, Klemola P, Kaijalainen S, Paananen A, Simonen ML, Vuorinen T, Roivainen M: Co-circulation of coxsackieviruses A6 and A10 in hand, foot and mouth disease outbreak in Finland. / J Clin Virol 2010,48(1):49鈥?4. CrossRef
  2. Osterback R, Vuorinen T, Linna M, Susi P, Hyypi盲 T, Waris M: Coxsackievirus A6 and hand, foot, and mouth disease, Finland. / Emerg Infect Dis 2009, 15:1485鈥?488. CrossRef
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• 作者单位：Fan Yang (1)
  Ting Zhang (1)
  Yongfeng Hu (1)
  Xiaofang Wang (2)
  Jiang Du (1)
  Yufen Li (3)
  Shaoxia Sun (3)
  Xiuhua Sun (4)
  Zhifang Li (3)
  Qi Jin (1)
  
  1. State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing, People鈥檚 Republic of China
  2. Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PRC
  3. LinYi People鈥檚 Hospital, Linyi, Shandong, PRC
  4. Heze Center for Disease Control and Prevention, Heze, Shandong, PRC
  
• ISSN：1743-422X

文摘

Background In China, a rapid expansion of Hand, foot, and mouth disease (HFMD) outbreaks has occurred since 2004 and HFMD has become an important issue for China. However, people are still only concerned with human enterovirus 71(HEV-71) and coxsackie virus A16 (CV-A16). Much of what is known about the other enterovirus infections relies on fractional evidence and old epidemic data, with little knowledge concerning their distribution. To alert potential threatens of the other enteroviruses, our study genetically characterized specimens from different regions of China and yielded novel information concerning the circulating and phylogenetic characteristics of enteroviral strains from HFMD cases. Findings A total of 301 clinical throat swabs were randomly obtained from patients suffering from HFMD from the southern, northern and central regions of China during outbreaks in 2009. 266 of 301 (88.4%) HFMD cases were found positive for HEV and seven genotypes, HEV-71, CV-A16, -B5, -A4, -A6, -A10, and -A12, were detected. Conclusions The HFMD pathogen compositions in the different regions of China were significantly different. HFMD epidemics might persist for a long time in China due to the multiple pathogen compositions, the enteroviral characteristic of recombination and co-infection, the ever-increasing travel and migration and the deficiency of effective vaccine. Our study deserves the attention on HFMD control and vaccine development.