EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions

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• 作者：Yonglun Luo ; Jenny Blechingberg ; Ana Miguel Fernandes ; Shengting Li…
• 关键词：Transcriptional ; regulation ; Transcription ; factors ; RNA ; processing ; ChIP ; sequencing ; RNA ; binding ; Gene ; expression ; Amyotrophic lateral sclerosis ; Fronto ; temporal lobar degeneration
• 刊名：BMC Genomics
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：16
• 期：1
• 全文大小：1,577 KB
• 刊物主题：Life Sciences, general; Microarrays; Proteomics; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics;
• 出版者：BioMed Central
• ISSN：1471-2164

文摘

Background FUS (TLS) and EWS (EWSR1) belong to the FET-protein family of RNA and DNA binding proteins. FUS and EWS are structurally and functionally related and participate in transcriptional regulation and RNA processing. FUS and EWS are identified in translocation generated cancer fusion proteins and involved in the human neurological diseases amyotrophic lateral sclerosis and fronto-temporal lobar degeneration.