Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress

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• 作者：Shuping Li (1) (2)
  Jinghao Sheng (1) (3)
  Jamie K. Hu (1)
  Wenhao Yu (1)
  Hiroko Kishikawa (1)
  Miaofen G. Hu (1)
  Kaori Shima (4)
  David Wu (5)
  Zhengping Xu (3)
  Winnie Xin (6)
  Katherine B. Sims (6)
  John E. Landers (7)
  Robert H. Brown Jr. (7)
  Guo-fu Hu (1)
  
• 关键词：Ribonuclease 4 ; Angiogenin ; Angiogenesis ; Neurogenesis ; Neuroprotection ; Amyotrophic lateral sclerosis (ALS)
• 刊名：Angiogenesis
• 出版年：2013
• 出版时间：April 2013
• 年：2013
• 卷：16
• 期：2
• 页码：387-404
• 全文大小：1476KB
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• 作者单位：Shuping Li (1) (2)
  Jinghao Sheng (1) (3)
  Jamie K. Hu (1)
  Wenhao Yu (1)
  Hiroko Kishikawa (1)
  Miaofen G. Hu (1)
  Kaori Shima (4)
  David Wu (5)
  Zhengping Xu (3)
  Winnie Xin (6)
  Katherine B. Sims (6)
  John E. Landers (7)
  Robert H. Brown Jr. (7)
  Guo-fu Hu (1)
  
  1. Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Box 5069, Boston, MA, 02111, USA
  2. State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
  3. Institute of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou, China
  4. Division of Oral Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
  5. Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
  6. Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
  7. Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
  
• ISSN：1573-7209

文摘

Altered RNA processing is an underlying mechanism of amyotrophic lateral sclerosis (ALS). Missense mutations in a number of genes involved in RNA function and metabolisms are associated with ALS. Among these genes is angiogenin (ANG), the fifth member of the vertebrate-specific, secreted ribonuclease superfamily. ANG is an angiogenic ribonuclease, and both its angiogenic and ribonucleolytic activities are important for motor neuron health. Ribonuclease 4 (RNASE4), the fourth member of this superfamily, shares the same promoters with ANG and is co-expressed with ANG. However, the biological role of RNASE4 is unknown. To determine whether RNASE4 is involved in ALS pathogenesis, we sequenced the coding region of RNASE4 in ALS and control subjects and characterized the angiogenic, neurogenic, and neuroprotective activities of RNASE4 protein. We identified an allelic association of SNP rs3748338 with ALS and demonstrated that RNASE4 protein is able to induce angiogenesis in in vitro, ex vivo, and in vivo assays. RNASE4 also induces neural differentiation of P19 mouse embryonal carcinoma cells and mouse embryonic stem cells. Moreover, RNASE4 not only stimulates the formation of neurofilaments from mouse embryonic cortical neurons, but also protects hypothermia-induced degeneration. Importantly, systemic treatment with RNASE4 protein slowed weight loss and enhanced neuromuscular function of SOD1 G93A mice.