Screening of New Caledonian and Vanuatu medicinal plants for antiprotozoal activity

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• 作者：Billo ; M. ; Fournet ; A. ; Cabalion ; P. ; Waikedre ; J. ; Bories ; C. ; Loiseau ; P. ; Prina ; E. ; Rojas de Arias ; A. ; et. al.
• 关键词：New Caledonia ; Vanuatu ; Leishmanicidal activity ; Trypanocidal activity
• 刊名：Journal of Ethnopharmacology
• 出版年：2005
• 期刊代码：26_03788741
• 类别：pha
• 出版时间：January 15, 2005
• 卷：96
• 期：3
• 页码：569-575
• 文件大小：80.3 K

摘要

Sixty-seven extracts of 30 medicinal plants traditionally used in New Caledonia or Vanuatu by healers to treat inflammation, fever and in cicatrizing remedies were evaluated in vitro for their antiprotozoal activity against Leishmania donovani, Leishmania amazonensis and Trypanosoma cruzi. Among the selected plants, Pagiantha cerifera was the most active against both Leishmania species; four extracts were active against promastigotes of Leishmania donovani at EC₅₀ values inferior to 5 μg/ml. Garcinia pedicillata extract had an EC₅₀ value of 12.5 μg/ml against intracellular amastigotes of Leishmania amazonensis. Alone Amborella trichopoda reduced by more of 80%the trypomastigotes of Trypanosoma cruzi in the blood.