Homeostatic niche specification among naïve and activated B cells: A growing role for the BLyS family of receptors and ligands
- 作者：Crowley ; Jenni E. ; Treml ; Laura S. ; Stadanlick ; Jason E. ; Carpenter ; Erica ; Cancro ; Michael P.
- 关键词：B lymphocyte ; Homeostasis ; BLyS
- 刊名：Seminars in Immunology
- 出版年：2005
- 期刊代码：105_10445323
- 类别：imm
- 出版时间：June, 2005
- 卷：17
- 期：3
- 页码：193-199
- 文件大小：130 K
摘要
B lymphocyte homeostasis encompasses the establishment and maintenance of independently regulated niches, within which cells compete for viability promoting resources. The BLyS/BLyS receptor family controls the size and composition of these niches, by governing the selection and survival of most peripheral B cells. Moreover, different receptor-ligand sets from this family dominate the regulation of various B cell subsets. These observations suggest a model whereby the regulation of BLyS receptors by differentiative and stimulatory cues yield characteristic BLyS receptor signatures, thus specifying homeostatic niche and competitive advantage.