Preparation and characterization of carboxyl functionalization of chitosan derivative magnetic nanoparticles

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• 作者：Gui-yin Li ; Ke-long Huang ; Yu-ren Jiang ; Ping Ding ; Dong-liang Yang
• 关键词：Nanostructures ; Magnetic properties ; Transmission electron microscopy (TEM)
• 刊名：Biochemical Engineering Journal
• 出版年：2008
• 期刊代码：9_1369703x
• 类别：ce
• 出版时间：1 July 2008
• 卷：40
• 期：3
• 页码：408-414
• 文件大小：806 K

摘要

The functionalized magnetic Fe₃O₄-chitosan derivative nanoparticles have been prepared by the covalent binding of alpha-ketoglutaric acid chitosan (KCTS) onto the surface of Fe₃O₄ magnetic nanoparticles via carbodiimide activation. Transmission electron microscopy (TEM) showed that the KCTS-bound Fe₃O₄ nanoparticles were regular spheres with a mean diameter of 26 nm. X-ray diffraction (XRD) patterns indicated that the Fe₃O₄ nanoparticles were pure Fe₃O₄ with a spinel structure, and the binding of KCTS did not result in a phase change. The binding of KCTS to the Fe₃O₄ nanoparticles was also demonstrated by the measurement of thermogravimetric analysis (TGA), differential scanning calorimetry analysis (DSC) and Fourier transform infrared (FTIR) spectra. Magnetic measurement revealed that the saturated magnetization of the KCTS-bound Fe₃O₄ nanoparticles reached 24.8 emu g⁻¹ and the nanoparticles showed the characteristics of superparamagnetism.