Biologic properties and vaccine potential of the staphylococcal poly-N-acetyl glucosamine surface polysaccharide

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• 作者：Maira-Litran ; Tomas ; Kropec ; Andrea ; Goldmann ; Donald ; Pier ; Gerald B.
• 关键词：Staphylococcus ; Polysaccharide ; Vaccine
• 刊名：Vaccine
• 出版年：2004
• 期刊代码：89_0264410x
• 类别：imm
• 出版时间：February 17, 2004
• 卷：22
• 期：7
• 页码：872-879
• 文件大小：157 K

摘要

Staphylococci have become the most common causes of nosocomial bacterial infections, and this fact, along with increasing problems associated with antimicrobial resistance, spurs the need for finding immunotherapeutic alternatives to prevent and possibly treat these infections. Most virulent, clinical isolates of both coagulase-negative staphylococci (CoNS) and Staphylococcus aureus carry the ica locus which encodes proteins that synthesize a polymer of β-1-6 linked N-acetyl glucosamine residues (PNAG). Animal studies have shown purified PNAG can elicit protective immunity against both CoNS and S. aureus, suggesting its potential as a broadly protective vaccine for many clinically important strains of staphylococci.