Mechanisms of self-inactivation in anergic T cells

详细信息	查看全文 | 推荐本文 |

• 作者：Rut Valdor ; Fernando Macian ; ^{fernando.macian@einstein.yu.edu}
• 关键词：Tolerance ; T cell anergy ; NFAT ; Regulatory T cell
• 刊名：Inmunolog铆a
• 出版年：2010
• 期刊代码：pca191_02139626
• 类别：med
• 出版时间：January-March 2010
• 卷：29
• 期：1
• 页码：20-33
• 文件大小：245 K

摘要

Self-reactive T cells that escape negative selection in the thymus must be inactivated or eliminated in the periphery. In response to a partial or suboptimal stimulation, T cells become anergic and unable to proliferate and express cytokines in response subsequent re-encounters with antigen. Calcium signaling plays a central role in the induction of anergy, causing the activation of a calcium/calcineurin/NFAT-dependent cell-intrinsic program of self-inactivation. This review will focus on our current knowledge on the mechanisms that regulate the expression of an anergyspecific program of gene expression in T cells, and how the proteins encoded by those genes impose a state of functional unresponsiveness by targeting and modulating the activity of crucial events required for the activation of T cells, which include downregulation of TCR signaling and inhibition of cytokine transcription.