Biotechnological significance of toxic marine dinoflagellates
- 作者：F. Garcia Camacho ; J. Gallardo Rodrí ; guez ; A. Sá ; nchez Miró ; n ; M.C. Ceró ; n Garcí ; a ; E.H. Belarbi ; Y. Chisti ; E. Molina Grima
- 关键词：Algal toxins ; Ciguatera fish poisoning ; Diarrhetic shellfish poisoning ; Dinoflagellates ; Marine toxins ; Neurotoxic shellfish poisoning ; Paralytic shellfish poisoning
- 刊名：Biotechnology Advances
- 出版年：2007
- 期刊代码：22_07349750
- 类别：abs
- 出版时间：March-April 2007
- 卷：25
- 期：2
- 页码：176-194
- 文件大小：474 K
摘要
Dinoflagellates are microalgae that are associated with the production of many marine toxins. These toxins poison fish, other wildlife and humans. Dinoflagellate-associated human poisonings include paralytic shellfish poisoning, diarrhetic shellfish poisoning, neurotoxic shellfish poisoning, and ciguatera fish poisoning. Dinoflagellate toxins and bioactives are of increasing interest because of their commercial impact, influence on safety of seafood, and potential medical and other applications. This review discusses biotechnological methods of identifying toxic dinoflagellates and detecting their toxins. Potential applications of the toxins are discussed. A lack of sufficient quantities of toxins for investigational purposes remains a significant limitation. Producing quantities of dinoflagellate bioactives requires an ability to mass culture them. Considerations relating to bioreactor culture of generally fragile and slow-growing dinoflagellates are discussed. Production and processing of dinoflagellates to extract bioactives, require attention to biosafety considerations as outlined in this review.