• 作者：N. Rodrí ; guez-Gonzá ; lez^a ; C. Pé ; rez-Rico^b ; ^{cinta.perezrico@gmail.com} ; R. L&#243 ; pez-Para Gimé ; nez^c ; J. Aré ; valo-Serrano^d ; B. Del Amo Garcí ; a^e ; L. Calzada Domingo^e ; L. Flores Ruiz^e ; R. Blanco^f
• 关键词：Orbitopatí ; a de Graves ; Mú ; sculos extraoculares ; Resonancia nuclear magné ; tica ; Exoftalmos ; Actividad clí ; nica (CAS)
• 刊名：Archivos de la Sociedad Espa帽ola de Oftalmolog铆a
• 出版年：2011
• 期刊代码：pca66_03656691
• 类别：med
• 出版时间：November 2011
• 卷：86
• 期：11
• 页码：351-357
• 文件大小：363 K

lass="h4">Objective

To evaluate the orbital structures and to establish correlations with disease activity and severity in patients with Graves鈥?hyperthyroidism and orbitopathy (GO) using short-tau inversion-recovery (STIR) sequence magnetic resonance imaging (MRI).

lass="h4">Methods

Observational, cross-sectional, case-control study. Twenty-eight patients with euthyroid status after treatment and GO (GO group) and 15 control subjects (control group) were included. Patients underwent a complete ophthalmologic examination and were then assessed according to the EUGOGO (European Group on Graves鈥?Orbitopathy) recommendations. Muscle cross-sectional areas, orbital tissue volumes and the signal intensity ratio (SIR) from the most inflamed extraocular muscle were calculated using a STIR-T2 weighted sequence MRI. Correlations between clinical and MRI measurements were analyzed.

lass="h4">Results

Enlargements in the cross-sectional areas and volumes were significant for most EOMs (P < .001), but not for the lateral rectus muscle cross-sectional area. A significant difference in SIR values between patients with GO and control subjects (P < .001) was found. No significant correlations were found between muscle cross-sectional areas, orbital tissue volumes, SIR values and the clinical activity parameters.

lass="h4">Conclusions

Given the small sample size of our study, with the obvious need for larger clinical trials, we were unable to demonstrate that the STIR sequences in MRI are a sensitive tool in assessing patients with longstanding GO in order to detect inflammatory changes and activity follow-up, possibly because it is in inactive phase. Meanwhile, it is still necessary to continue performing a thorough clinical evaluation in the therapeutic management of GO.