• 作者：M. Albert^a ; ^{albert_marfon@gva.es} ; E. Beltrá ; n^b ; L. Martí ; nez-Costa^a
• 关键词：Rituximab ; Queratitis perifé ; rica ulcerativa ; Artritis reumatoide
• 刊名：Archivos de la Sociedad Espa帽ola de Oftalmolog铆a
• 出版年：2011
• 期刊代码：pca66_03656691
• 类别：med
• 出版时间：April 2011
• 卷：86
• 期：4
• 页码：118-120
• 文件大小：158 K

Clinical case

We report two cases of patients affected by longstanding rheumatoid arthritis who developed a severe form of peripheral ulcerative keratitis (PUK). Neither of them had an optimal biological and clinical control of their systemic illness despite being treated with several disease-modifying antirheumatic drugs (DMARDs) and biologic therapy. High-dose systemic corticosteroids were given to treat the PUK without any success. Rituximab resulted in a favourable response with resolution of the corneal lesions and optimal control of their systemic illness.

Discussion

Rituximab may be an additional tool to arrest progressive rheumatoid arthritis-associated PUK that is refractory to other drugs.