三孢布拉霉发酵产番茄红素的研究进展
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  • 英文篇名:Advance in production of lycopene by Blakeslea trispora
  • 作者:王强 ; 余晓斌
  • 英文作者:WANG Qiang;YU Xiao-Bin;The Key Laboratory of Industrial Biotechnology,Ministry of Education,School of Biotechnology,Jiangnan University;
  • 关键词:番茄红素 ; 三孢布拉霉 ; 菌种选育 ; 工艺优化 ; 化学调控
  • 英文关键词:Lycopene,Blakeslea trispora,Genetic breeding,Process optimization,Chemical regulation
  • 中文刊名:WSWT
  • 英文刊名:Microbiology China
  • 机构:江南大学生物工程学院工业生物技术教育部重点实验室;
  • 出版日期:2014-07-30 11:01
  • 出版单位:微生物学通报
  • 年:2015
  • 期:v.42;No.282
  • 基金:江苏省自然科学基金项目(No.BK20130130)
  • 语种:中文;
  • 页:WSWT201502027
  • 页数:7
  • CN:02
  • ISSN:11-1996/Q
  • 分类号:197-203
摘要
番茄红素是一种重要的类胡萝卜素,在生物体中具有抗氧化、抗衰老、提高免疫力等生理功能。虽然已经有部分企业实现了番茄红素的工业化生产,但产量仍然是制约三孢布拉霉发酵生产番茄红素的重要因素。在本实验室研究的基础上,本文结合近年来国内外学者的研究成果,从遗传育种、发酵工艺优化、化学调控等方面综述了提高三孢布拉霉中番茄红素产量的研究进展,并展望了未来的研究方向。
        Lycopene is a member of important carotenoids with antioxidation,anti-aging,immunity enhancement,and other physiological functions.Although commercial production of lycopene has been realized in some enterprise,poor lycopene production remains the key restricting factor for lycopene biosynthesis by Blakeslea trispora.Combining with the latest achievements of lycopene production by B.trispora,this mini-review summarized the genetic breeding of strain,the optimization of fermentation process,chemical regulation,and the prospects of future research.
引文
[1]Kong KW,Khoo HE,Prasad KN,et al.Revealing the power of the natural red pigment lycopene[J].Molecules,2010,15(2):959-987
    [2]Prakash A,Kumar A.Lycopene protects against memory impairment and mito-oxidative damage induced by colchicine in rats:An evidence of nitric oxide[J].European Journal of Pharmacology,2013,721(1):373-381
    [3]Li X,Xu J.Meta-analysis of the association between dietary lycopene intake and ovarian cancer risk in postmenopausal women[J].Scientific Reports,2014.DOI:10.1038/srep04885
    [4]Published online Jaswir I,Noviendri D,Hasrini RF,et al.Carotenoids:Sources,medicinal properties and their application in food and nutraceutical industry[J].Journal of Medicinal Plants Research,2011,5(33):7119-7131
    [5]Ciegler A.Microbial carotenogenesis[J].Advances in Applied Microbiology,1965,7:1-14
    [6]Rohmer M,Knani M,Simonin P,et al.Isoprenoid biosynthesis in bacteria:a novel pathway for the early steps leading to isopentenyl diphosphate[J].Biochemical Journal,1993,295(2):517-524
    [7]Ladygin VG.Biosynthesis of carotenoids in the chloroplasts of algae and higher plants[J].Russian Journal of Plant Physiology,2000,47(6):796-814
    [8]Goodwin TW.Biosynthesis of carotenoids and plant triterpenes[J].Biochemical Journal,1971,123(3):293-329
    [9]Mehta B,Cerdá-Olmedo E.Mutants of carotene production in Blakeslea trispora[J].Applied Microbiology and Biotechnology,1995,42(6):836-838
    [10]Van DEH.Relationship between sexuality and carotene synthesis in Blakeslea trispora[J].Journal of Bacteriology,1968,96(4):1298-1303
    [11]Wang JD,Yuan QP,Qian ZM.The new advances in trisporicacid–a key metabolite in fermentation production ofβ-carotene[J].Microbiology China,2004,31(3):147-150(in Chinese)王见冬,袁其朋,钱忠明.β-胡萝卜素发酵过程中关键的代谢产物——三孢酸[J].微生物学通报,2004,31(3):147-150
    [12]Rodriguez M,Teresa A,De E,et al.Improved method of production of lycopene by the fermentation of selected strains of Blakeslea trispora:EP Patent,1,471,151[P].2004-10-27
    [13]Wang Q,Luo W,Gu QY,et al.Enhanced lycopene content in Blakeslea trispora by effective mutation-screening method[J].Applied Biochemistry and Biotechnology,2013,171(7):1692-1700
    [14]Wang Q,Feng LR,Luo W,et al.Mutation breeding of lycopene-producing strain Blakeslea trispora by a novel atmospheric and room temperature plasma(ARTP)[J].Applied Biochemistry and Biotechnology,2014,Published online
    [15]Mehta BJ,Obraztsova IN,Cerda-Olmedo E.Mutants and intersexual heterokaryons of Blakeslea trispora for production ofβ-carotene and lycopene[J].Applied And Environmental Microbiology,2003,69(7):4043-4048
    [16]Rodriguez-Saiz M,Paz B,De JL,et al.Blakeslea trispora genes for carotene biosynthesis[J].Appllied Environmental Microbiology,2004,70(9):5589-5594
    [17]Li Y.Study on silencing of the car RA gene by RNA interference in filamentous fungus Blakeslea trispora[D].Beijing:Doctoral Dissertation of Beijing University of Chemical Technology,2009(in Chinese)李晔.RNA干扰三孢布拉氏霉菌番茄红素环化酶基因的研究[D].北京:北京化工大学博士学位论文,2009
    [18]Lorca-Pascual JM,Murcia-Flores L,Garre V,et al.The RING-finger domain of the fungal repressor crg A is essential for accurate light regulation of carotenogenesis[J].Molecular Microbiology,2004,52(5):1463-1474
    [19]Nicolás-Molina FE,Navarro E,Ruiz-Vazquez RM.Lycopene over-accumulation by disruption of the negative regulator gene crg A in Mucor circinelloides[J].Appllied Microbiology Biotechnology,2008,78(1):131-137
    [20]Quiles-Rosillo MD,Ruiz-Vazquez RM,Torres-Martinez S,et al.Light induction of the carotenoid biosynthesis pathway in Blakeslea trispora[J].Fungal Genetics and Biology,2005,42(2):141-153
    [21]Roukas T,Niavi P,Kotzekidou P.A new medium for spore production of Blakeslea trispora using response surface methodology[J].World Journal of Microbiology and Biotechnology,2010,27(2):307-317
    [22]Filotheou A,Nanou K,Papaioannou E,et al.Application of response surface methodology to improve carotene production from synthetic medium by Blakeslea trispora in submerged fermentation[J].Food and Bioprocess Technology,2012,5(4):1189-1196
    [23]López-Nieto MJ,Costa J,Peiro E,et al.Biotechnological lycopene production by mated fermentation of Blakeslea trispora[J].Appllied Microbiology Biotechnology,2004,66(2):153-159
    [24]Varzakakou M,Roukas T,Kotzekidou P.Effect of the ratio of(+)and(-)mating type of Blakeslea trispora on carotene production from cheese whey in submerged fermentation[J].World Journal of Microbiology and Biotechnology,2010,26(12):2151-2156
    [25]Ciegler A,Arnold M,Anderson RF.Microbiological production of carotenoids.V.Effect of lipids and related substances on production of beta-carotene[J].Applied Microbiology,1959,7(2):98-101
    [26]Mantzouridou F,Tsimidou MZ,Roukas T.Performance of crude olive pomace oil and soybean oil during carotenoid production by Blakeslea trispora in submerged fermentation[J].Journal of Agricultural and Food Chemistry,2006,54(7):2575-2581
    [27]Mantzouridou F,Tsimidou MZ.Carotenoid pattern in Blakeslea trispora grown on oil-enriched substrates with regard to triacylglycerol species accumulation[J].European Journal of Lipid Science and Technology,2007,109(1):3-10
    [28]Vereschagina OA,Memorskaya AS,Tereshina VM.The role of exogenous lipids in lycopene synthesis in the mucoraceous fungus Blakeslea trispora[J].Microbiology,2010,79(5):593-601
    [29]Hsu WJ,Yokoyama H,Coggins JCW.Carotenoid biosynthesis in Blakeslea trispora[J].Phytochemistry,1972,11(10):2985-2990
    [30]Pegklidou K,Mantzouridou F,Tsimidou MZ.Lycopene production using Blakeslea trispora in the presence of 2-methyl imidazole:yield,selectivity,and safety aspects[J].Journal of Agricultural And Food Chemistry,2008,56(12):4482-4490
    [31]Xiu Y,Yuan QP.The application of tobacco and MPTA during lycopene production by Blakeslea trispora[J].Journal of Beijing University of Chemical Technology(Natural Science Edition),2009,36(1):81-84(in Chinese)修宇,袁其朋.烟草和MPTA对三孢布拉氏霉合成番茄红素的影响[J].北京化工大学学报:自然科学版,2009,36(1):81-84
    [32]Dandekar S,Modi VV,Jani UK.Chemical regulators of carotenogenesis by Blakeslea trispora[J].Phytochemistry,1980,19(5):795-798
    [33]Desai HG,Modi VV.Stimulation of carotenogenesis by penicillin in Blakeslea trispora[J].Phytochemistry,1977,16(9):1373-1376
    [34]Kim SW,Seo WT,Park YH.Enhanced production of beta-carotene from Blakeslea trispora with Span 20[J].Biotechnology Letters,1997,19(6):561-562
    [35]Wang YS,Wang JD,Yuan QP,et al.The effect of mycelial mophology on lycopene fermentation[J].Microbiology China,2003,30(6):47-51(in Chinese)王永生,王见冬,袁其朋,等.菌体形态对发酵法生产番茄红素的影响[J].微生物学通报,2003,30(6):47-51
    [36]Shi YQ,Xin XL,Yuan QP.Improved lycopene production by Blakeslea trispora with isopentenyl compounds and metabolic precursors[J].Biotechnology Letters,2012,34(5):849-852
    [37]Hu X,Sun J,Yuan Q.Improvedβ-carotene biosynthesis and gene transcription in Blakeslea trispora with arachidonic acid[J].Biotechnology Letters,2012,34(11):2107-2111
    [38]Jeong JC,Lee IY,Kim SW,et al.Stimulation ofβ-carotene synthesis by hydrogen peroxide in Blakeslea trispora[J].Biotechnology Letters,1999,21(8):683-686
    [39]Nanou K,Roukas T,Papadakis E.Oxidative stress and morphological changes in Blakeslea trispora induced by enhanced aeration during carotene production in a bubble column reactor[J].Biochemical Engineering Journal,2011,54(3):172-177
    [40]Nanou K,Roukas T.Oxidative stress response of Blakeslea trispora induced by iron ions during carotene production in shake flask culture[J].Applied Biochemistry and Biotechnology,2013,169(8):2281-2289
    [41]Zhu Y,Yuan QP,Wang H.Enhancement of lycopene production by Blakeslea trispora using oxygen-vectors and surface active agents[J].Microbiology China,2006,33(1):90-93(in Chinese)朱艳,袁其朋,王航.添加氧载体及表面活性剂对番茄红素发酵的影响[J].微生物学通报,2006,33(1):90-93
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