摘要
选择了药典收载的4种淫羊藿与巫山淫羊藿药材共5个物种33份样品,比较不同加热处理导致的淫羊藿苷含量的变化,结果表明淫羊藿药材或粉末150℃加热处理30 min是适宜的处理方法,淫羊藿苷的增加量最大,但该条件并不能将前体化合物3’’’-羰基-2″-β-L-喹诺糖基淫羊藿苷(3’’’-carbonyl-2″-β-L-quinovosyl icariin,CQICA)全部转化为淫羊藿苷,且同时淫羊藿苷也有部分降解。在来自5个物种药材中,朝鲜淫羊藿的淫羊藿苷增加量较大,一般增加1～3倍,心叶淫羊藿和柔毛淫羊藿一般也有增加,但增加幅度不同样品差别很大,箭叶淫羊藿和巫山淫羊藿则少有增加,或稍微有所降低。
The change of icariin( ICA) content in thirty-three samples of five Epimedium species listed in the Chinese Pharmacopoeia( 2015 edition),including E. brevicornu,E. sagittatum,E. pubescens,E. koreanum,and E. wushanense has been investigated in this study. The results indicated that the optimized process procedure was baking at 150 ℃ for 30 min,and 3’’’-carbonyl-2″-β-L-quinovosyl icariin( CQICA) could not be translated into ICA and ICA could be converted under this heating process condition. ICA increased remarkably after the heating process by 1-3 times in E. brevicornu,E. wushanense and E. koreanum,and increased lightly in E. brevicornum and E. pubescens,while ICA slightly increased or decreased in E. sagittatum and E. wushanense.
引文
[1]刘春明,李丽,刘志强,等.炮制前后朝鲜淫羊藿化学成分的变化规律研究[J].分析测试学报,2004,23(1):67.
[2]蔡垠,陈彦,贾晓斌,等.受热温度和时间对淫羊藿中黄酮成分含量的影响[J].中国中药杂志,2007,32(22):2441.
[3]朱粉霞,赵永刚,贾晓斌,等.淫羊藿炮制前后UPLC-PDA-MS的指纹图谱研究[J].化学学报,2012,70(5):635.
[4]仲玲利,徐娟,张鑫,等.炮制对巫山淫羊藿黄酮类成分的影响[J].中国医药导报,2011,30(8):29.
[5]陈彦,贾晓斌,蔡垠,等.温度和受热时间——影响淫羊藿苷含量的两个关键因素[J].中成药,2007,29(7):1038.
[6]孙娥,陈玲玲,贾晓斌,等.药材品种与受热时间对淫羊藿饮片中主要黄酮类成分的影响规律研究[J].中药材,2012,35(9):1402.
[7]李冬雪,杜守颖.淫羊藿提取浓缩干燥过程中的淫羊藿苷含量变化[J].河北中医,2011,33(4):587.
[8]高希梅,李飞,周玉新.温度对油炙巫山淫羊藿总黄酮和淫羊藿苷含量的影响[J].北京中医药大学学报,2005,28(3):62.
[9]Sun Xinguang,Li Qi,Zhang Jie,et al. The reason leading to the increase of icariin in Herba Epimedii by heating process[J].J Pharm Biomed Anal,2018,149:525.
[10]郭宝林,肖培根.中药淫羊藿主要种类评述[J].中国中药杂志,2003,28(4):303.
