摘要
目的考察甲硝唑阴道凝胶的阴道刺激性和皮肤过敏性,为其临床应用的安全性提供依据。方法采用刺激性试验,在实验兔的阴道给药,连续给药7天后,观察并记录可能出现的阴道刺激反应;采用皮肤过敏性试验,分别于第0、7、14天在豚鼠皮肤给药致敏,第28天激发给药,观察豚鼠皮肤或全身过敏反应。结果甲硝唑阴道凝胶外用给药未引起阴道刺激性和过敏性反应。结论甲硝唑阴道凝胶用于治疗细菌性阴道炎是较安全的。
Objective To investigate the vaginal irritation and skin sensitization associated with metronidazole vaginal gel,and to provide evidence for its clinical application. Methods An irritation test was carried out on rabbits for vaginal administration. After 7 days of continuous administration,possible vaginal irritation was observed and recorded. A skin allergy test was administered on guinea pig skin on days 0,7,and 14. Sensitization was initiated on day 28 to observe guinea pig skin or systemic allergic reactions. Results The topical administration of metronidazole vaginal gel did not cause vaginal irritation or allergic reactions. Conclusions Metronidazole vaginal gel is safe for the treatment of bacterial vaginosis.
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