摘要
中医除从外形认识肥胖外,尚从虚和实角度认识肥胖,流行病学调查显示,气虚质(虚性体质)和痰湿质(实性体质)是肥胖两大主要体质。代谢组学研究显示,两者虽同为肥胖,能量代谢却呈现相反趋势。新近研究表明,巨噬细胞自噬可通过启动(垃圾回收及储能)和降解(垃圾焚化及供能)实现代谢调节,任何阶段障碍均可造成肥胖,明确障碍所在阶段对肥胖防治意义重大。由此提出,开展虚实体质肥胖自噬比较研究的设想,观察其在起始和降解两个阶段之不同,为肥胖虚实体质分型提供科学依据,转变肥胖认知理念,也为从自噬不同阶段靶点进行肥胖新药研发奠定基础。
Despite of identifying obesity by the appearance, traditional Chinese medicine(TCM) found a new way of analyzing it from the viewpoint of access and deficiency. Epidemiological investigation shows that qi deficiency(deficiency constitution) and phlegm dampness(solid constitution) are the two main constitutions of obesity. Metabolomic studies have shown that although both are obese, energy metabolism shows an opposite trend. Recent studies showed that macrophage autophagy can achieve metabolic regulation by the initiation step-garbage collection(storage) and degradation step-garbage incineration(energy supply) and disorders of either step can cause obesity, so to clarify where the inhibition occurs is significant in clinical obesity prevention and treatment. Based on above, we put forward to carry out the comparative study about the autophagy condition of the two obesity phenotypes, and confirm the different in the two steps between them. This not only provides scientific basis for differentiating obesity by access and deficiency constitution, changes the conception of obesity, but also provides a basis for the research and development of obesity drugs from different aspects of autophagy.
引文
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