摘要
目的:探索精神分裂症患者语义加工时N400成分异常与思维形式障碍(FTD)的关系。方法:对21例伴有FTD的精神分裂症患者(SZ-FTD组)、16例不伴FTD精神分裂症患者(SZ-n FTD组)及19名健康对照者(对照组)进行语义启动任务时的脑电事件相关电位检测,分析各组在3种语义启动任务下(图片-词语一致、相关、不相关)N400波幅和潜伏期。结果:3种语义启动任务下精神分裂症患者N400波幅显著低于对照组(F(1,54)=9.60,P<0.01),潜伏期显著长于对照组(F(1,54)=4.20,P<0.05);当图片-词语不相关时,SZ-FTD组N400波幅显著低于对照组,顶区N400潜伏期显著长于对照组(P均<0.05);SZ-n FTD组与对照组N400波幅及潜伏期比较差异无统计学意义。结论:精神分裂症患者语义加工时的N400活动异常,伴有FTD的患者语义加工损害更严重。
Objective: To explore the relationship of impaired semantic processing reflected by abnormal N400 component and formal thought disorder in patients with schizophrenia. Method: Twenty-one schizophrenic patients with formal thought disorder(FTD)(SZ-FTD group),16 schizophrenia patients without FTD(SZ-n FTD group) and 19 normal controls(NC group) were recruited and participated in the picture-word semantic priming task. The event related potential component N400 was evaluated from all participants and N400 amplitudes and latencies were compared among the 3 groups across 3 conditions with the priming picture and the target word matched,related or unrelated. Results: Schizophrenia patients had significantly lower N400 amplitudes(F(1,54) = 9. 60,P < 0. 01) and longer latencies(F(1,54) = 4. 20,P < 0. 05) in all three conditions of the semantic primary task than normal controls. In the condition with the picture and target unrelated,SZ-FTD group had lower N400 amplitudes and longer N400 latencies at the top area of brain than the NC group(all P <0. 05); but did not differ between SZ-n FTD and NC groups. Conclusion: Schizophrenic patients have impaired semantic-related N400 activity and SZ-FTD patients may have more severe impairments of semantic processing.
引文
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