摘要
目的研究小儿肺热清颗粒联合丙酸氟替卡松对小儿支气管哮喘患者的临床疗效。方法 120例患者随机分为对照组和实验组,每组60例,对照组给予丙酸氟替卡松,实验组在对照组基础上加用小儿肺热清颗粒,疗程14 d。然后,检测总有效率、临床症状消失时间、血清炎性因子(TNF-α、hs-CRP、IL-4)水平、肺功能指标(FEV1、PEFR、FEV1/FVC)、不良反应发生率。结果治疗后,实验组总有效率显著高于对照组(P<0. 05),临床症状消失时间显著缩短(P<0. 05); 2组TNF-α、hs-CRP、IL-4水平、FEV1、PEFR、FEV1/FVC显著改善(P<0. 05),以实验组更明显(P<0. 05); 2组不良反应发生率无显著差异(P>0. 05)。结论小儿肺热清颗粒联合丙酸氟替卡松可改善小儿支气管哮喘患者血清炎性因子水平和肺功能,临床疗效和安全性良好。
AIM To study the clinical effects of Xiao'er Feireqing Granules combined with fluticasone propionate on pediatric bronchial asthma patients. METHODS One hundred and twenty patients randomly assigned into control group and trial group,60 cases in each group,went on 14-day intervention of fluticasone propionate( control group),or Xiao'er Feireqing Granules+fluticasone propionate( trial group). Subsequently,total effective rate,clinical symptom disappearing time,serum inflammatory factors( TNF-α,hs-CRP,IL-4) levels,lung function indices( FEV1,PEFR,FEV1/FVC),adverse reaction incidence rate were detected. RESULTS The trial group demonstrated significantly higher total effective rate than the control group( P < 0. 05),and markedly shortened clinical symptom disappearing time( P<0. 05). Both groups shared obvious post-treatment improvements in TNF-α,hs-CRP,IL-4 levels,FEV1,PEFR,FEV1/FVC( P<0. 05),especially for those in the trial group( P<0. 05);yet no significant difference in adverse reaction incidence rate existed in the two groups( P> 0. 05).CONCLUSION Xiao 'er Feireqing Granules combined with fluticasone propionate may be of good clinical efficacy and safety for the management of pediatric bronchial asthma patients due to their improvement in serum inflammatory factors levels and lung function.
引文
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