摘要
血管内皮细胞(VEC)是覆盖于血管内膜表面的单层扁平鳞状上皮细胞,其构成血管壁的生物屏障,不仅属于一种保护性屏障,还能够产生一些自体分泌物用于调节体内平衡和血管紧张度。VEC衰老可导致血管功能受损,是心血管系统(CVS)主要的危险因素,并与心血管疾病(CVD)有着密切的关系。然而,VEC衰老的机制以及VEC衰老对血管功能的影响尚不完全清楚。本综述总结了VEC衰老的特征及其相关分子机制,并对年龄相关CVD进行了阐述。
The vascular endothelial cell( VEC) is a single layer of flat squamous epithelium covering the intima of the blood vessel. It constitutes a biological barrier to the blood vessel wall. It is not only a protective barrier but also produces some autocrine secretion. The substance is used to regulate homeostasis and vascular tone and has a variety of biological functions. VECsenescence can lead to vascular dysfunction,which is a major risk factor for cardiovascular system( CVS) and has a close relationship with cardiovascular disease( CVD). However,themechanism of VEC senescence and the effects of VEC senescence on vascular function are not fully understood. This review summarizes the characteristics of VEC senescence and its related molecular mechanisms,and describes age-related CVD.
引文
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