摘要
目的探讨老年高血压患者半乳糖凝集素3及尿微量白蛋白与左室肥厚关系。方法随机选取符合纳入标准的老年高血压合并左室肥厚(LVH组)及非左室肥厚患者各120例(NLVH组),匹配两组年龄、性别比例及住院时间。采用条件Logistic回归分析LVH独立危险因素。结果单因素分析:LVH与病程、血压控制情况、体质指数、NT-pro BNP、文化程度、Gal-3及MAU相关;多因素Logistic回归,病程、血压控制情况、Gal-3及MAU进入模型,其OR(95%CI)分别为1.062(1.001~2.237)、1.643(1.527~5.185)、2.816(2.231~8.872)、3.736(3.151~11.391)。结论老年高血压患者病程、血压控制情况、Gal-3及MAU与LVH有显著相关性,且为独立危险因素。
Objective To investigate the relationship of galectin 3(Gal-3)and microalbuminuria(MAU)with left ventricular hypertrophy(LVH)in elderly patients with hypertension. Methods 120 patients with LVHwere included in the study as LVH group and another patients with non-LVH group as NLVH group with the age,sex ratio and length of stay matched to the LVH group. The conditional Logistic regression was used to analyze theindependent risk factors of LVH. Results The single factor analysis showed a positive correlation of LVH with thecourse of disease,blood pressure control,BMI,NT-pro BNP,Gal-3,MAU and education level. By multivariateLogistic regression,course of disease,blood pressure,Gal-3 and MAU were included in the model,with the OR(95%CI)of 1.062(1.001~2.237),1.643(1.527~5.185),2.816(2.231~8.872)and 3.736(3.151~11.391).Conclusion As independent risk factors,the course of disease,control of blood pressure,Gal-3 and MAU aresignificantly correlated with LVH.
引文
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