摘要
除了单核/巨噬细胞有重要的致动脉粥样硬化(AS)作用外,T细胞在AS中也起着重要作用。辅助性T细胞1型(Th1)通过强烈的致凋亡作用影响AS,其他T细胞亚群如Th2和Th17也参与AS的发生发展。调节性T细胞(Tregs)还与Th2相关细胞因子相互作用抑制AS发展。然而现在对T细胞在AS中的具体作用机制尚不明确。本文就T细胞在AS中的作用及这些细胞可能为AS研究和治疗提供的方向作一综述。
T cells play an important role in atherosclerosis(AS) besides monocytes and macrophages. The T helper cell type 1(Th1) affect AS via strong apoptotic effect, other T cell subgroups are also involved in occurrence and development of AS, such as Th2 and Th17. The interaction between regulatory T cells(Tregs) and Th2 related cytokines can inhibit AS development. However, mechanism of T cells in AS is still not clear. The present article made a review on role of T cells in AS and their possible guidance for research and treatment of AS.
引文
[1]Ren HY,Khera A,de Lemos JA,et al.Soluble endothelial cell-selective adhesion molecule and incident cardiovascular events in a multiethnic population[J].Am Heart J,2017,191:55-61.
[2]Libby P,Lichtman AH,Hansson GK.Immune effector mechanisms implicated in atherosclerosis:from mice to humans[J].Immunity,2013,38(6):1092-1104.
[3]GisterA,Hansson GK.The immunology of atherosclerosis[J].Nat Rev Nephrol,2017,13(6):368-380.
[4]Taleb S.Inflammation in atherosclerosis[J].Arch Cardiovasc Dis,2016,109(12):708-715.
[5]Li Y,Liu X,Duan W,et al.Batf3-dependent CD8α+Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5Expression in Plaque Macrophages[J].EBio Med,2017,18:188-198.
[6]Zhao Y,Dai XY,Zhou Z,et al.Leucine supplementation via drinking water reduces atherosclerotic lesions in apoE null mice[J].Acta Pharmacol Sin,2016,37(2):196-203.
[7]Zhong Y,Tang H,Wang X,et al.Intranasal immunization with heat shock protein 60induces CD4(+)CD25(+)GARP(+)and type 1regulatory T cells and inhibits early atherosclerosis[J].Clin Exp Immunol,2016,183(3):452-468.
[8]Benagiano M,Gerosa M,Romagnoli J,et al.β2Glycoprotein IRecognition Drives Th1 Inflammation in Atheroselerotic Plagues of Patients with Primay Antiphospholipid Syndrome[J].J Immunol,2017,198(7):2640-2648.
[9]Ji Q,Zeng Q,Huang Y,et al.Elevated plasma IL-37,IL-18,and IL-18BP concentrations in patients with acute coronary syndrome[J].Mediators Inflamm,2014,2014:165742.
[10]Antoniades C,Bakogiannis C,Tousoulis D,et al.TheCD40/CD40ligand system:linking inflammation with atherothrombosis[J].J Am Coll Cardiol,2009,54(8):669-677.
[11]Meng K,Zeng Q,Lu Q,et al.Valsartan Attenuates Atherosclerosis via Upregulating the Th2Immune Response in Prolonged Angiotensin II-Treated ApoE(-/-)Mice[J].Mol Med,2015,21:143-153.
[12]Zhao XN,Li YN,Wang YT.Interleukin-4regulates macrophage polarization via the MAPK signaling pathway to protect against atherosclerosis[J].Genet Mol Res,2016,15(1).
[13]Silveira A,McLeod O,Strawbridge RJ,et al.Plasma IL-5concentration and subclinicalcarotid atherosclerosis[J].Atherosclerosis,2015,239(1):125-130.
[14]IBC 50KCAD Consortium.Large-scale gene-centric analysis identifies novel variants for coronary artery disease[J].PLoSGenet,2011,7(9):e1002260.
[15]Tsiantoulas D,Bot I,Ozsvar-Kozma M,et al.Increased Plasma IgE Accelerate Atherosclerosis in Secreted IgM Deficiency[J].Circ Res,2017,120(1):78-84.
[16]Ishigami T,Abe K,Aoki I,et al.Anti-interleukin-5and multiple autoantibodies are associated with human atherosclerotic diseases and serum interleukin-5levels[J].FASEB J,2013,27(9):3437-3445.
[17]Cardilo-Reis L,Gruber S,Schreier SM,et al.Interleukin-13protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype[J].EMBO Mol Med,2012,4(10):1072-1086.
[18]Miller AM,Xu D,Asquith DL,et al.IL-33reduces the development of atherosclerosis[J].J Exp Med,2008,205(2):339-346.
[19]Lim H,Kim YU,Sun H,et al.Proatherogenic conditions promote autoimmune T helper 17cell responses in vivo[J].Immunity,2014,40(1):153-165.
[20]Nanke Y,Yago T,Kotake S.The Role of Th17Cells in the Pathogenesis of Behcet's Disease[J].J Clin Med,2017,6(7).pii:E74.
[21]Danzaki K,Matsui Y,Ikesue M,et al.Interleukin-17Adeficiency accelerates unstable atherosclerotic plaque formation in apolipoprotein E-deficient mice[J].Arterioscler Thromb Vasc Biol,2012,32(2):273-280.
[22]Usui F,Kimura H,Ohshiro T,et al.Interleukin-17deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice[J].Biochem Biophys Res Commun,2012,420(1):72-77.
[23]Madhur MS,Funt SA,Li L,et al.Role of interleukin 17in inflammation,atherosclerosis,and vascular function in apolipoprotein e-deficient mice[J].Arterioscler Thromb Vasc Biol,2011,31(7):1565-1572.
[24]Taleb S,Tedgui A,Mallat Z.IL-17and Th17cells in atherosclerosis:subtle and contextual roles[J].Arterioscler Thromb Vasc Biol,2015,35(2):258-264.
[25]Akhavanpoor M,Akhavanpoor H,Gleissner CA,et al.The Two Faces of Interleukin-17A in Atherosclerosis[J].Curr Drug Targets,2017,18(7):863-873.
[26]Ladeiras-Lopes R,Koenig W.Interleukin-17in atherosclerosis:Still a long road ahead[J].Int J Cardiol,2016,202:932.
[27]Simon T,Taleb S,Danchin N,et al.Circulating levels of interleukin-17and cardiovascular outcomes in patients with acute myocardial infarction[J].Eur Heart J,2013,34(8):570-577.
[28]GisterA,Robertson AK,Andersson J,et al.Transforming growth factor-βsignaling in T cells promotes stabilization of atherosclerotic plaques through an interleukin-17-dependent pathway[J].Sci Transl Med,2013,5(196):196ra100.
[29]Kyaw T,Toh BH,Bobik A.Foxp3+CD4+Regulatory T-Cell Subtypes and Atherosclerosis[J].Circ Res,2016,119(11):1151-1153.
[30]Ji Q,Meng K,Yu K,et al.Exogenous interleukin 37ameliorates atherosclerosis via inducing the Treg response in ApoE-deficient mice[J].Sci Rep,2017,7(1):3310.
[31]Klingenberg R,Gerdes N,Badeau RM,et al.Depletion of FOXP3+regulatory T cells promotes hypercholesterolemia and atherosclerosis[J].J Clin Invest,2013,123(3):1323-1334.
[32]Dinh TN,Kyaw TS,Kanellakis P,et al.Cytokine therapy with interleukin-2/anti-interleukin-2 monoclonal antibodycomplexes expands CD4+CD25+Foxp3+regulatory T cells and attenuates development and progression of atherosclerosis[J].Circulation,2012,126(10):1256-1266.
[33]Kita T,Yamashita T,Sasaki N,et al.Regression of atherosclerosis with anti-CD3antibody via augmenting a regulatory T-cell response in mice[J].Cardiovasc Res,2014,102(1):107-117.
[34]Wigren M,Kolbus D,Dunr P,et al.Evidence for a role of regulatory T cells in mediating the atheroprotective effect of apolipoprotein B peptide vaccine[J].J Intern Med,2011,269(5):546-556.
[35]Huo Y,Chu Y,Guo L,et al.Cortisol is associated with low frequency of interleukin 10-producing B cells in patients with atherosclerosis[J].Cell Biochem Funct,2017,35(3):178-183.
[36]Tian YL,Wang LJ,Wu Y,et al.Pioglitazone ameliorates atherosclerosis in apoE knockout mice through transforming growth factor-β/Smad signaling and adaptive T cell immunity[J].Nan Fang Yi Ke Da Xue Xue Bao,2017,37(8):1003-1009.
