摘要
迷迭香酸是一种在自然界广泛存在的多酚羟基化合物,具有多种药理作用,如抗氧化、抗菌等。药代动力学研究表明,迷迭香酸在体内可被代谢为结合态和/或甲基化形式,主要经尿液排出体外。该文综述了迷迭香提取物的抗肿瘤作用与机制研究进展。
Rosmarinic acid is a kind of polyphenolic hydroxyl compound widely found in nature. It has a variety of pharmacological effects,such as anti-oxidation and antibacterial. Pharmacokinetic studies have shown that rosmarinic acid can be metabolized into conjugated and/or methylated forms in vivo,which is mainly excreted from the body through urine. In this paper,the research progress of the anti-tumor effect and mechanism of the extract of Rosmarinus officinalis were reviewed.
引文
[1] BODAI BI,TUSO P. Breast Cancer Survivorship:A Comprehensive Review of Long-term Medical Issues and Lifestyle Recommendations[J]. Perm J,2015,19(2):48-79.
[2]段庚仙.恶性肿瘤化疗的毒副作用及其防治[J].肿瘤研究与临床,2004,15(6):353-354.
[3]吴国利,聂剑初,颜卉君,等.几种中药抗癌作用的生化研究[J].北京师范大学学报(自然科学版),1982,57(2):57-67.
[4] DA ROCHA AB,LOPES RM,SCHWARTSMANN G. Natural products in anticancer therapy[J]. Curr Opin Pharmacol,2001(1):364-369.
[5] CUVELIER ME,BERSET C,RICHARD H. Antioxidant Constituents in Sage(Salvia officinalis)[J]. J Agric Food Chem,1994,42:665-669.
[6] GONZLEZ-VALLINAS M,REGLERO G,RAMREZ DE MOLINA A. Rosemary(Rosmarinus officinalis L.)Extract as a Potential Complementary Agent in Anticancer Therapy[J]. Nutr Cancer,2015,67(8):1221-1229.
[7] PETIWALA SM,JOHNSON JJ. Diterpenes from rosemary(Rosmarinus officinalis):Defining their potential for anti-cancer activity[J]. Cancer Lett,2015,367(2):93-102.
[8] OSAKABE N,YASUDA A,NATSUME M,et al. Rosmarinic acid inhibits epidermal inflammatory responses:anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model[J].Carcinogenesis,2004,25(4):549-557.
[9] BAKOTA EL,WINKLER-MOSER JK,BERHOW MA,et al.Antioxidantactivity and sensory evaluation of a rosmarinic acidenriched extract of Salvia officinalis[J]. J Food Sci,2015,80(4):C711-C717.
[10] ROCHA J,EDUARDO-FIGUEIRA M,BARATEIRO A,et al.Anti-inflammatory effect of rosmarinc acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation[J]. Basic Clin Pharmacol Toxicol,2015,116(5):398-413.
[11] HUR YG,SUH CH,KIM S,et al. Rosmarinic acid induces apoptosis of activated T cells from rheumatoid arthritis patients via mitochondrial pathway[J]. J Clin Immunol,2007,27(1):36-45.
[12] LI X,YU C,LU Y,et al. Pharmacokinetics,tissue distribution,metabolism,and excretion of depside salts from Salvia miltiorrhizain rats[J]. Drug Metab Dispos,2007,35(2):234-239.
[13] LAI XJ,ZHANG L,LI JS,et al. Comparative pharmacokinetic and bioavailability studies of three salvianolic acids after the administration of Salviae miltiorrhizae alone or with synthetical borneol in rats[J]. Fitoterapia,2011,82:883-888.
[14] KONISHI Y,KOBAYASHI S. Transepithelial transport of rosmarinic acid in intestinal Caco-2cellmonolayers[J]. Biosci Biotechnol Biochem,2005,69(3):583-591.
[15] BABA S,OSAKABE N,NATSUME M,et al. Orally administered rosmarinic acid is present as the conjugated and/or methylated forms in plasma,and is degraded and metabolized to conjugated forms of caffeicacid,Ferulic acidandm-coumaricacid[J]. Life Sci,2004,75(2):165-178.
[16] BABA S,OSAKABE N,NATSUME M,et al. Absorption,metabolism,degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans[J]. EurJ Nutr,2005,44(1):1-9.
[17] SCHECKEL KA,DEGNER SC,ROMAGNOLO DF. Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines[J]. J Nutr,2008,138(11):2098-2105.
[18] KARTHIKKUMAR V,SIVAGAMI G,VINOTHKUMA R,et al.Modulatory efficacy of rosmarinc acid on premalignant lesions and antioxidant status in 1,2-dimethylhydrazine induced rat colon cancarcinogenesis[J]. Environ Toxicol Pharmacol,2012,34(3):949-958.
[19] KARMOKAR A,MARCZYLO TH,CAI H,et al. Dietary intake of rosmarinic acid by ApcMin mice,a model of colorectal carcinogenesis:levels of parent agent in the target tissue and effect on adenoma development[J]. Mol Nutr Food Res,2012,56:775-783.
[20] XAVIER CPR,LIMA CF,FERNANDES-FERREIRA M,et al.Salvia fruticosa,Salvia officinalis and rosmarinic acid induce apoptosis and inhibit proliferation of human colorectal cell lines:The role in MAPK/ERK pathway[J]. Nutr Cancer,2009,61:564-571.
[21] XU Y,XU G,LIU L,et al. Anti-invasion effect of rosmarinic acid via the extracellular signal-regulated kinase and oxidation-reduction pathway in Ls174-T cells[J]. J Cell Biochem,2010,111(2):370-379.
[22] KISPERT S,MCHOWAT J. Recent insights into cigarette smoking as a lifestyle risk factor for breast cancer[J]. Breast Cancer,2017,5(9):127-132.
[23] ZHAO PW,LEE DY,MA ZZ,et al. Effect of carnosol against proliferative activity of breast cancer cells and its estrogen receptor subtype's mediation and regulation mechanisms[J]. Zhongguo Zhong Yao Za Zhi,2014,39(17):3344-3348.
[24] BERDOWSKA I,ZIELINSKI B,FECKA I,et al. Cytotoxic impact of phenolics from Lamiaceae specieson human breast cells[J].Food Chem,2013,141(2):1313-1321.
[25] RENZULLI C,GALVANO F,PIERDOMENICO L,et al. Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line(HepG2)[J].J Appl Toxicol,2004,24(4):289-296.
[26] LIN CS,KUO CL,WANG JP,et al. Growth inhibitory and apoptosis inducing effect of Perilla frutescens extract on human hepatoma HepG2 cells[J]. J Ethnopharmacol,2007,112(3):557-567.
[27]徐丹,肖卫红,胡志敏.迷迭香酸诱导肝癌HepG2细胞凋亡的作用机制研究[J].中国药师,2017,20(3):427-429.
[28] COLLIGNON A,WANQUET A,MAITRE E,et al. Prolymphocytic Leukemia:New Insights in Diagnosis and in Treatment[J].Curr Oncol Rep,2017,19(4):29-33.
[29] MOON DO,KIM MO,LEE JD,et al. Rosmarinic acid sensitizes cell death through suppression of TNF-α-induced NF-κB activation and ROS generation in human leukemia U937 cells[J].Cancer Lett,2010,288(2):183-191.
[30] SAIKO P,STEINMANN MT,SCHUSTER H,et al. Epigallocatechin gallate,ellagic acid,and rosmarinic acid perturb dNTP pools and inhibit de novo DNA synthesis and proliferation of human HL-60 promyelocytic leukemia cells:Synergism with arabinofuranosylcytosine[J]. Phytomedicine,2015,22(1):213-222.
[31] TAI J,CHEUNG S,WU M,et al. Antiproliferation effect of Rosemary(Rosmarinus officinalis)on human ovarian cancer cells in vitro[J]. Phytomedicine,2012,19(5),436-443.
[32] SAMARGHANDIAN S,AFSHARI JT,DAVOODI S. Modulation of programmed cell death by honey bee in human prostate adenocarcinoma[J]. J Medicin Plants Res,2010(4):2551-2556.
[33] SAMARGHANDIAN S,AFSHARI JT,DAVOODI S. Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell Line pc-3[J]. Clinics(Sao Paulo),2011,66(6):1073-1079.
[34] SAMARGHANDIAN S,SHABESTARI MM. DNA fragmentation and apoptosis induced by safranal in human prostate cancer cell line[J]. Indian J Urol,2013,29(3):177-183.
[35] YESIL-CELIKTAS O,SEVIMLI C,BEDIR E,et al. Inhibitory Effects of Rosemary Extracts,Carnosic Acid and Rosmarinic Acid on the Growth of Various Human Cancer Cell Lines[J].Plant Foods Hum Nutr,2010,65(2):158-163.
[36] HAN S,YANG S,CAI,Z,et al. Anti-Warburg effect of rosmarinic acid via miR-155 in gastric cancer cells[J]. Drug Des,Devel Ther,2015,9:2695-2703.
[37] LEE J,KIM YS,PARK D. Rosmarinic acid induces melanogenesis through protein kinase A activation signaling[J]. Biochem Pharmacol,2007,74(7):960-968.
[38] TAO L,WANG S,ZHAO Y,et al. Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 activity[J]. Phytopharm,2014,21(11):1473-1482.
[39] MIN KJ,JUNG KJ,KWON TK. Carnosic acid induces apoptosis through reactive oxygen species-mediated endoplasmic reticulum stress induction in human renal carcinoma Caki cells[J].Journal of Cancer Prevention,2014,19(3):170-178.
[40] IBANEZ C,VALDES A,GARCIA-CANAS V,et al. Global Foodomics strategy to investigate the health benefits of dietary constituents[J]. Journal of chromatography A,2012,1248:139-153.
[41] BARON JA,COLE BF,MOTT L,et al. Neoplastic and antineoplastic effects of beta-carotene on colorectal adenoma recurrence:results of a randomized trial[J]. J Natl Cancer Inst,2003,95(10):717-722.
[42] GREENBERG ER,BARON JA,TOSTESON TD,et al. A clinical trial of antioxidant vitamins to prevent colorectal adenoma[J]. N Engl J Med,1994,331(3):141-147.
[43] MOONEY LA,MADSEN AM,TANG D,et al. Antioxidant vitamin supplementation reduces benzo(a)pyrene-DNA adducts and potential cancer risk in female smokers[J]. Cancer Epidemiol Biomarkers Prev,2005,14(1):237-242.
[44] YI W,WETZSTEIN HY. Anti-tumorigenic activity of five culinary and medicinal herbs grown under greenhouse conditions and their combination effects[J]. J Sci Food Agric,2011,91(10):1849-1854.
[45] ILAS S,KNEZ Z,CETOJEVI-SIMIN D,et al. In vitro antioxidant and antiproliferative activity of three rosemary(Rosmarinus officinalis L.)extract formulations[J]. International Journal of Food Science&Technology,2012,47:2052-2062.
[46] VICENTE G,MOLINA S,GONZALEZ-VALLINAS M,et al.Supercritical rosemary extracts,their antioxidant activity and effect on hepatic tumor progression[J]. The Journal of Supercritical Fluids,2013,79:101-108.
[47] HUANG MT,HO CT,WANG ZY,et al. Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid[J]. Cancer Res,1994,54(3):701-708.
[48] HUANG MC,CHEN HY,HUANG HC,et al. C2GnT-M is downregulated in colorectal cancer and its re-expression causes growth inhibition of colon cancer cells[J]. Oncogene,2006,25(23):3267-3276.
[49] PLOUZEK CA,CIOLINO HP,CLARKE R,et al. Inhibition of P-glycoprotein activity and reversal of multidrug resistance in vitro by rosemary extract[J]. Eur J Cancer,1999,35(10):1541-1545.
