摘要
目的探讨社区轻度认知障碍者中医体质、辨证分型与血清炎症因子的关系。方法纳入118例社区轻度认知障碍患者,参照《中医体质分类与判断》中的有关标准辨别中医体质类型,参照《中药新药临床研究指导原则》中的有关标准进行中医辨证分型,采用ELISA法检测炎症因子(IL-1β、IL-6)水平;比较不同体质类型、不同中医证型IL-1β、IL-6水平的差异。结果 (1)118例轻度认知障碍患者中,平和质65例(55.1%),阳虚质25例(21.2%),其他偏颇体质28例(23.7%)。(2)118例轻度认知障碍患者中,脾肾亏虚型49例(41.5%),阴虚阳亢型18例(15.3%),气血不足型17例(14.4%),其他证型34例(28.8%)。(3)平和质组和非平和质组比较,IL-1β和IL-6水平差异均有统计学意义(P<0.05,P<0.01);脾肾亏虚型与非脾肾亏虚型比较,IL-1β和IL-6水平差异均有统计学意义(P<0.05)。结论社区轻度认知障碍患者的中医体质类型以平和质为多见,中医辨证以脾肾亏虚型为主;平和质组的IL-1β、IL-6水平高于非平和质组,脾肾亏虚组IL-1β、IL-6水平低于非脾肾亏虚组。
Objective To discuss the relationships between serum inflammatory factors and constitution of Chinese medicine or syndrome differentiation and classification in community patients with mild cognitive impairment. Methods 118 community patients with mild cognitive impairment were included. The constitutional types of Chinese medicine were differentiated according to the relevant standards in Classification and Judgement of Constitutions of Chinese Medicine,and syndrome differentiation and pattern classification of Chinese medicine were preformed based on the relevant standards in Guidelines for Clinical Research of Chinese Medicine New Drugs. The levels of inflammatory factors IL-1β and IL-6 were detected by ELISA. The differences on the levels of IL-1β and IL-6 between different constitutional type and syndrome patterns were compared. Results(1)In 118 community patients with mild cognitive impairment,there were 65 cases in normal constitution( accounted for 55. 1%),25 cases in yang deficiency constitution( accounted for 21. 2%) and 28 cases in other biased constitutions( accounted for 23. 7%).(2)In 118 community patients with mild cognitive impairment,there were 49 cases with syndrome of deficiency of spleen and kidney( accounted for41. 5%),18 cases with syndrome of hyperactivity of yang due to yin deficiency( accounted for 15. 3%),17 cases with syndrome of deficiency of qi and blood( accounted for 14. 4%) and 34 cases with other syndrome patterns( accounted for 28. 8%).(3)There were statistically significant differences on the levels of IL-1βand IL-6 between normal constitution group and other constitutions group( P < 0. 05,P < 0. 01). There were statistically significant differences on the levels of IL-1β and IL-6 between patients with syndrome of deficiency of spleen and kidney and patients with other syndrome patterns( P < 0. 05). Conclusion In community patients with mild cognitive impairment,the most common constitutional type of Chinese medicine is normal constitution and the syndrome of deficiency of spleen and kidney is the main pattern in syndrome differentiation of Chinese medicine. The levels of IL-1 β and IL-6 in patients with normal constitution are higher than those in patients with other constitutions,and the levels of IL-1β and IL-6 in patients with syndrome of deficiency of spleen and kidney are lower than those in patients with other syndrome patterns.
引文
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