摘要
目的探讨孤独症谱系障碍(ASD)儿童自我面孔识别能力及其与血清脑源性神经营养因子(BDNF)水平、年龄和症状之间的关系。方法采用自我面孔识别任务(SFRT)对31例未治疗过且不共患其他疾病的ASD儿童进行测试,并与39例年龄性别匹配的正常儿童作比较,以儿童孤独症评定量表(CARS)评定症状严重程度,BDNF采用酶联夹心免疫吸附法检测。结果患者组SFRT反应时长与对照组比较[(56.39±3.60)s vs(54.00±3.50)s],差异有统计学意义(P<0.01),自我面孔成分所占百分比[(67.94±4.45)%]高于对照组[(65.06±4.33)%],差异有统计学意义(P<0.01)。患者组血清BDNF浓度[(10.86±1.15)ng/ml]低于对照组[(11.70±1.06)ng/ml],差异有统计学意义(P<0.01);相关分析显示,患者组SFRT反应时与血清BDNF浓度呈负相关(r=-0.389,P<0.05),患者组年龄、CARS评分与SFRT的反应时长及百孔合成百分比无显著相关性。结论 ASD儿童存在自我面孔识别能力的损害,血清BDNF浓度低于正常儿童,血清BDNF水平与自我面孔识别加工存在相关性。
引文
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