摘要
目的:优选麦冬提取工艺。方法:以麦冬皂苷D﹑麦冬总皂苷含量和浸膏得率为评价指标,采用层次分析法(AHP)﹑CRITIC法以及AHP-CRITIC混合加权法确定权重,均匀设计试验优化提取工艺。结果:最佳提取工艺为:12倍71%乙醇,回流提取2次,每次0. 5 h。结论:AHP-CRITIC混合加权法真实客观,重复性好,表明优化得到的最佳提取工艺合理稳定,切实可行。为生脉分散片的生产工艺优化提供科学基础。
Objective: To optimize the extraction process of Ophiopogon japonicus. Methods: With the content of Ophiopogon saponin D,the total saponin content of Ophiopogon japonicus and the extract yield as the evaluation indices,the weights were determined by analytic hierarchy process( AHP), criteria importance through intercriteria correlation( CRITIC) and AHP-CRITIC combined with weighting method and the uniform design experiment to optimize the extraction process. Results: The optimum extraction technology conditions were as follows: adding 12-fold amount of 71% ethanol and reflux extracting 3 times with0. 5h for each time. Conclusion: AHP-CRITIC combined with weighting method is objective and reproducible,indicating that the optimal extraction process is reasonable, stable and feasible, which provides scientific basis for the production process optimization of Shengmai dispersible tablets.
引文
1金虹,王化东,何礼,等.川产麦冬及其须根组织学与麦冬皂苷量的对比研究[J].中草药,2014,45(7):1002-1005
2张璐欣,周学谦,李德坤,等.麦冬多糖的化学组成、分析方法和药理作用研究进展[J].药物评价研究,2017,40(2):279-284
3彭婉,马骁,王建,等.麦冬化学成分及药理作用研究进展[J].中草药,2018,49(2):477-488
4黄光辉,孙连娜.麦冬多糖的研究进展[J].现代药物与临床,2012,27(5):523-529
5马海波.麦冬化学成分的研究[D].北京:北京中医药大学硕士学位论文,2013
6刘榴,张白嘉.麦冬及有效部位药理作用研究进展[J].四川中医2010,12(28):39-41
7何礼,金虹,梁雪兰,等.HPLC测定川麦冬块根及须根中的麦冬皂苷D[J].华西药学杂志,2014,29(5):583-584
8缪菊连,黄照昌,王成军,等.HPLC-ELSD法测定生脉饮中麦冬皂苷D[J].中成药,2015,37(2):462-464
9吴发明,杨海燕,杨瑞山,等.四川麦冬质量评价研究[J].中药材,2016,39(8):1803-1808
10朱亚楠,李萍,王满,等.多指标均匀设计法优选痤疮消凝胶提取工艺[J].中国实验方剂学杂志,2015,21(9):6-9
11贺佳,高尔生.综合评价中权重系数及标准化方法的研究[J].中国公共卫生,2001,17(11):1048-1050
12万林,章国宝,陶杰.基于AHP-CRITIC的电梯安全性评估[J].安全与环境学报,2017,17(5):1696-1700
13陈娇,余娇,江敏瑜,等.基于多指标权重分析和正交设计法对三七跌打损伤软膏提出工艺的探究[J].中药材,2017,40(2):412-415
14林韵涵,李崇明,李晓东,等.湖北麦冬有效部位总皂苷的提取纯化工艺研究[J].中药材,2013,36(5):803-806
15杨铭,周昕,谢瑞芳,等.用层次分析法结合CRITIC法研究复方自身清颗粒提取工艺的多指标权重[J].药学服务与研究,2009,9(1):36-39
