摘要
糖尿病心肌病(diabetic cardiomyopathy, DCM)是一种基于糖尿病,排除心脏本身疾病导致的独立的缺血性心肌疾病。DCM的发病机制由多因素造成,目前并不十分明确,其主要由心肌细胞的损伤、血糖浓度增高、能量代谢紊乱及微血管病变引起。脂联素(adiponectin, APN)具有降血糖、调血脂、抗凋亡、抗炎症反应、抗氧化作用,也能预防动脉粥样硬化,与DCM的发生发展具有密切关系。本文就APN在DCM中作用的研究进展作一综述。
Diabetic cardiomyopathy(DCM) is an independent ischemic heart disease that occurs on the basis of diabetes, excluding diseases originated from the heart itself. The pathogenesis of DCM is caused by multiple factors and is still not well elucidated. It involves the injury of cardiac myocytes, hyperglycemia, energy metabolism disorder, and cardiac microvascular disease. Adiponectin(APN) has been found to be able to reduce the level of glycemia and regulate blood lipids, and has anti-apoptotic, anti-inflammatory, and antioxidant properties, as also be able to prevent atherosclerosis, and has close relationship with the development of DCM. Therefore, this article describes and summarizes the role of adiponectin in DCM.
引文
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